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18668-00-3

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18668-00-3 Usage

General Description

Propanoic acid, 2-(acetyloxy)-, (2R)- is a chemical compound that is also known as ibuprofen. It is a nonsteroidal anti-inflammatory drug (NSAID) and is commonly used to relieve pain, reduce inflammation, and lower fever. It works by inhibiting the production of prostaglandins, which are responsible for transmitting pain signals in the body. Ibuprofen is available over-the-counter in various forms, including tablets, capsules, and as a topical gel. It is commonly used to treat conditions such as headaches, dental pain, menstrual cramps, muscle aches, and arthritis. Ibuprofen should be used with caution, as it can cause side effects such as stomach ulcers, kidney problems, and an increased risk of heart attack or stroke. It is important to follow the recommended dosage and consult a healthcare professional before using ibuprofen, especially for long-term use or in combination with other medications.

Check Digit Verification of cas no

The CAS Registry Mumber 18668-00-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,6,6 and 8 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 18668-00:
(7*1)+(6*8)+(5*6)+(4*6)+(3*8)+(2*0)+(1*0)=133
133 % 10 = 3
So 18668-00-3 is a valid CAS Registry Number.

18668-00-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-(-)-2-acetoxypropionic acid

1.2 Other means of identification

Product number -
Other names (2S)-2-acetoxypropionic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18668-00-3 SDS

18668-00-3Relevant articles and documents

Vancomycin binding to low-affinity ligands: Delineating a minimum set of interactions necessary for high-affinity binding

Loll, Patrick J.,Kaplan, Jeffrey,Selinsky, Barry S.,Axelsen, Paul H.

, p. 4714 - 4719 (1999)

Bacterial resistance to vancomycin has been attributed to the loss of an intermolecular hydrogen bond between vancomycin and its peptidoglycan target when cell wall biosynthesis proceeds via depsipeptide intermediates rather than the usual polypeptide int

Stereoisomeric lactoyl β methylcholine iodides. Interaction with cholinesterase and acetylcholinesterase

Chan,Robinson

, p. 1057 - 1060 (1974)

The preparation and absolute configuration of the stereoisomeric forms of lactoyl β methylcholine iodide with the 2 racemic forms of the molecule are reported. None of the stereoisomers were substrates for the enzyme acetylcholinesterase, whereas two stereoisomers (L lactoyl β methylcholine and D lactoyl L β methylcholine iodide) were poor substrates for cholinesterase. Results are analyzed in the light of previous studies of the chiral requirements of these 2 enzymes and an attempt is made to define the rate limiting or prohibited step in the enzyme catalyzed reaction with these compounds.

A simple procedure for the synthesis of enantiopure α-acetoxy ketones

Babudri, Francesco,Fiandanese, Vito,Marchese, Giuseppe,Punzi, Angela

, p. 2431 - 2440 (1999)

Cross-coupling reactions of α-acetoxy carboxylic acid chlorides with organocopper reagents, derived from Grignard reagents, cuprous bromide and lithium bromide, provide a simple and straightforward method for the synthesis of enantiopure α-acetoxy ketones.

Total Synthesis of (+)-Prunustatin A: Utility of Organotrifluoroborate-Mediated Prenylation and Shiina MNBA Esterification and Macrolactonization to Avoid a Competing Thorpe-Ingold Effect Accelerated Transesterification

Chojnacka, Maja W.,Batey, Robert A.

supporting information, p. 5671 - 5675 (2018/09/13)

A convergent total synthesis of (+)-prunustatin A is described through the assembly of two key fragments and a macrolactonization. Shiina MNBA couplings were used for the formation of each of the four ester bonds in the tetralactone ring, including the key macrocyclization which was essential to minimize competing Thorpe-Ingold accelerated transesterification. Other key steps included an organoboron-based prenylation using potassium prenyltrifluoroborate and a carbonyldiimidazole-mediated coupling to form the salicylamide.

Preparation method and application of 2-lactoyl aminobenzoic acid

-

Paragraph 0037; 0038, (2017/08/30)

The invention relates to a new medicinal application of a chiral compound. The chiral compound is chemically named as R-/S-2-lactoyl aminobenzoic acid and has a structural formula as follows: formula (shown in the description). The compound is initially extracted and separated from secondary metabolite of microorganisms and can be obtained by virtue of a chemical synthetic method. An initial pharmacology experiment shows that the compound has good pain-easing and anti-inflammation activities and relatively low stimulation to gastrointestinal tracts. Recent researches prove that the compound has relatively good anti-platelet aggregation and anti-thrombus activities and is expected to be a novel non-steroidal anti-platelet aggregation and anti-thrombus drug.

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