187998-35-2

Basic information

• Product Name: 1-(4-CHLOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
• Synonyms: 1-(4-CHLOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID;BUTTPARK 96\18-16;SALOR-INT L317632-1EA;4-Carboxy-1-(4-chlorophenyl)-5-methyl-1H-pyrazole, 4-Chloro-(4-carboxy-5-methyl-1H-pyrazol-1-yl)benzene
• CAS NO: 187998-35-2
• Molecular Formula: C₁₁H₉ClN₂O₂
• Molecular Weight: 236.65
• Mol File: 187998-35-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 201 °C
• Boiling Point: 406.3°C at 760 mmHg
• Flash Point: 199.5°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 2.48E-07mmHg at 25°C
• Refractive Index: 1.634
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(4-CHLOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(187998-35-2)
• EPA Substance Registry System: 1-(4-CHLOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(187998-35-2)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 187998-35-2(Hazardous Substances Data)

Usage

General Description

1-(4-Chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid is a chemical compound with the molecular formula C11H9ClN2O2. It is a pyrazole derivative with a carboxylic acid functional group. 1-(4-CHLOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID has potential applications in pharmaceutical research and drug development due to its structural features, which could potentially interact with biological targets and be used in the synthesis of new drugs. Its properties and reactivity make it a valuable building block for the synthesis of more complex organic compounds with potential medicinal applications. Additionally, its chlorophenyl and methyl substituents can impact its pharmacological activity and interactions with biological systems, making it of interest for further study in the field of medicinal chemistry.

InChI:InChI=1/C11H9ClN2O2/c1-7-10(11(15)16)6-13-14(7)9-4-2-8(12)3-5-9/h2-6H,1H3,(H,15,16)

Upstream product

• 169548-94-1 1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 134653-70-6 ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 1337864-12-6 1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid tert-butyl ester 

Downstream Products

• 288252-38-0 1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride 
• 671182-58-4 1-(4-chlorophenyl)-5-methypyrazole 
• 1194055-48-5 1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid (1-pyridin-3-yl-butyl)-amide 
• 1194055-26-9 1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid [1-(5-bromo-pyridin-3-yl)-butyl]-amide 
• 1194055-25-8 1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid [1-(5-methanesulfonyl-pyridin-3-yl)-butyl]-amide 
• 1194055-29-2 1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid [1-(5-methanesulfonylamino-pyridin-3-yl)-butyl]-amide 
• 1194055-38-3 1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid {1-[5-(3-hydroxy-propane-1-sulfonyl)-pyridin-3-yl]-butyl}-amide 
• 1194055-36-1 3-[5-(1-{[1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carbonyl]-amino}-butyl)-pyridine-3-sulfonyl]-propionic acid methyl ester 
• 288250-37-3 1-(4-chlorophenyl)-N-[3-cyano-(4-piperazin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide 

Relevant articles and documents

Discovery and optimization of pyrazole amides as antagonists of CCR1

A HTS screen for CCR1 antagonists afforded a novel sub-micromolar hit 5 containing a pyrazole core. In this report the design, optimization, and SAR of novel CCR1 antagonists based on a pyrazole core motif is presented. Optimization led to the advanced ca

Rearrangements of N-heterocyclic carbenes of pyrazole to 4-aminoquinolines and benzoquinolines

1-Phenyl-substituted pyrazolium salts, formed by quaternization of pyrazoles with benzyl halides or long-chain alkyl halides, deprotonate to pyrazol-3-ylidenes that undergo a sequence of ring-opening, ring-closure, and tautomerization to new substituted 4

Pyrazole-amides and sulfonamides as sodium channel modulators

Compounds of the present invention modulate PN3 in mammals and are useful in treating pain in mammals.