188112-49-4Relevant articles and documents
Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists
Liu, Weiguo,Hussain, Zahid,Zang, Yi,Sweis, Ramzi F.,Romero, F. Anthony,Finke, Paul E.,Moningka, Remond,Bao, Jianming,Plotkin, Michael A.,Shang, Jin,Dingley, Karen H.,Salituro, Gino,Murphy, Beth Ann,Howard, Andrew D.,Ujjainwalla, Feroze,Wood, Harold B.,Duffy, Joseph L.
supporting information, p. 1088 - 1093 (2018/10/24)
A series of structurally diverse azaspirodecanone and spirooxazolidinone analogues were designed and synthesized as potent and selective somatostatin receptor subtype 5 (SSTR5) antagonists. Four optimized compounds each representing a subseries showed imp
AROMATIC RING COMPOUND
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Paragraph 0346, (2015/03/03)
Provided is an aromatic ring compound having a glucagon antagonistic action, which is useful for the prophylaxis or treatment of diabetes and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof has a superior glucagon antagonistic action, and is useful as a glucagon antagonist, a glucose production inhibitor or an agent for the prophylaxis or treatment of diabetes and the like.
Novel S1P1 receptor agonists - Part 2: From bicyclo[3.1.0] hexane-fused thiophenes to isobutyl substituted thiophenes
Bolli, Martin H.,Velker, J?rg,Müller, Claus,Mathys, Boris,Birker, Magdalena,Bravo, Roberto,Bur, Daniel,De Kanter, Ruben,Hess, Patrick,Kohl, Christopher,Lehmann, David,Meyer, Solange,Nayler, Oliver,Rey, Markus,Scherz, Michael,Steiner, Beat
supporting information, p. 78 - 97 (2014/02/14)
Previously, we reported on the discovery of a novel series of bicyclo[3.1.0]hexane fused thiophene derivatives that serve as potent and selective S1P1 receptor agonists. Here, we discuss our efforts to simplify the bicyclohexane fused thiophene
