1882-56-0

Basic information

• Product Name: Phenyl(p-tolyl)acetic acid
• Synonyms: Phenyl(p-tolyl)acetic acid;(4-Methylphenyl)(phenyl)acetic acid;2-(4-Methylphenyl)-2-phenylethanoic acid, 4-[Carboxy(phenyl)methyl]toluene
• CAS NO: 1882-56-0
• Molecular Formula: C₁₅H₁₄O₂
• Molecular Weight: 226.27
• Mol File: 1882-56-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 309.1°C at 760 mmHg
• Flash Point: 154.9°C
• Appearance: /
• Density: 1.148g/cm³
• Vapor Pressure: 0.000283mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: Phenyl(p-tolyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Phenyl(p-tolyl)acetic acid(1882-56-0)
• EPA Substance Registry System: Phenyl(p-tolyl)acetic acid(1882-56-0)

Safety Data

• Hazardous Substances Data: 1882-56-0(Hazardous Substances Data)

Usage

General Description

Phenyl(p-tolyl)acetic acid is a chemical compound with a molecular formula C15H14O2. It is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs, particularly non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac and indomethacin. Phenyl(p-tolyl)acetic acid has also been studied for its potential anti-inflammatory and analgesic properties. Additionally, it has been investigated for its potential use in the treatment of depression and other neurological disorders. Overall, phenyl(p-tolyl)acetic acid has shown promise as a versatile and important chemical in the production of pharmaceuticals and in the study of potential therapeutic applications.

InChI:InChI=1/C15H14O2/c1-11-7-9-13(10-8-11)14(15(16)17)12-5-3-2-4-6-12/h2-10,14H,1H3,(H,16,17)

Upstream product

• 109-72-8 n-butyllithium 
• 60-29-7 diethyl ether 
• 620-83-7 1-methyl-4-(phenylmethyl)benzene 
• 5468-18-8 2-phenyl-3-p-tolyl-succinic acid diamide 
• 611-71-2 MANDELIC ACID 
• 108-88-3 toluene 
• 4870-65-9 2-bromophenylacetic acid 
• 532-28-5 (RS)-mandelonitrile 
• 779-14-6 p-methyl-a-phenylbenzylchloride 
• 201230-82-2 carbon monoxide 
• 102-96-5 (2-nitroethenyl)benzene 
• 18584-20-8 4-methylmandelic acid 
• 71-43-2 benzene 
• 7646-78-8 tin(IV) chloride 

Downstream Products

• 50353-99-6 1,2-diphenyl-2-p-tolylethanone 
• 25124-94-1 phenyl-p-tolyl-acetic acid amide 
• 33142-31-3 phenyl-p-tolyl-acetic acid anilide 
• 860743-69-7 phenyl-p-tolyl-acetic acid menthyl ester 
• 32435-32-8 4-methylbenzhydryl 4-nitrobenzoate 
• 98901-19-0 N-tert-butyl-2-phenyl-2-p-tolylacetamide 
• 1882-56-0 (+)-(4-methylphenyl)phenylacetic acid 
• 134-84-9 4-Methylbenzophenone 
• 611-95-0 4-carboxybenzophenone 
• 91-01-0 1,1-Diphenylmethanol 
• 76-84-6 triphenylmethyl alcohol 
• 519-73-3 triphenylmethane 
• 101-81-5 Diphenylmethane 
• 1061757-66-1 C₃₀H₂₉NO 

Relevant articles and documents

Visible-Light-Driven External-Reductant-Free Cross-Electrophile Couplings of Tetraalkyl Ammonium Salts

Cross-electrophile couplings between two electrophiles are powerful and economic methods to generate C-C bonds in the presence of stoichiometric external reductants. Herein, we report a novel strategy to realize the first external-reductant-free cross-electrophile coupling via visible-light photoredox catalysis. A variety of tetraalkyl ammonium salts, bearing primary, secondary, and tertiary C-N bonds, undergo selective couplings with aldehydes/ketone and CO2. Notably, the in situ generated byproduct, trimethylamine, is efficiently utilized as the electron donor. Moreover, this protocol exhibits mild reaction conditions, low catalyst loading, broad substrate scope, good functional group tolerance, and facile scalability. Mechanistic studies indicate that benzyl radicals and anions might be generated as the key intermediates via photocatalysis, providing a new direction for cross-electrophile couplings.

Highly para-Selective C?H Alkylation of Benzene Derivatives with 2,2,2-Trifluoroethyl α-Aryl-α-Diazoesters

Compared to the most popular directing-group-assisted strategy, the “undirected” strategy for C?H bond functionalization represents a more flexible but more challenging approach. Reported herein is a gold-catalyzed highly site-selective C(sp2)?H alkylation of unactivated arenes with 2,2,2-trifluoroethyl α-aryl-α-diazoesters. This protocol demonstrates that high site-selective C?H bond functionalization can be achieved without the assistance of a directing group. In this transformation, both the gold catalyst and trifluoroethyl group on the ester of the diazo compound play vital roles for achieving the chemo- and regioselectivity.

COBALT-CATALYZED SYNTHESIS OF α-ARYLPROPIONIC AND DIARYLACETIC ACIDS

The cobalt-catalyzed carbonylation of ArCH(R)X (R=CH3, C6H5; X=Cl, Br) in alcoholic solvents under atmospheric pressure of CO is reported.Selective, high yield synthesis of the corresponding acids ArCH(R)COOH can be achieved within a very narrow range of experimental conditions by controlling kinetically the reversible interconversion of intermediate aryl and alkylcobalt complexes.The important roles of the base and of the alcoholic medium are briefly discussed.