188576-49-0

Basic information

• Product Name: TERT-BUTYL 7-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
• Synonyms: TERT-BUTYL 7-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE;7-Hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
• CAS NO: 188576-49-0
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.31
• Mol File: 188576-49-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 140-142.5 °C
• Boiling Point: 391.376°C at 760 mmHg
• Flash Point: 190.497°C
• Appearance: /
• Density: 1.171g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: 2-8°C
• PKA: 10.22±0.20(Predicted)
• CAS DataBase Reference: TERT-BUTYL 7-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 7-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE(188576-49-0)
• EPA Substance Registry System: TERT-BUTYL 7-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE(188576-49-0)

Safety Data

• Hazardous Substances Data: 188576-49-0(Hazardous Substances Data)

Usage

Description

TERT-BUTYL 7-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE is a chemical compound that serves as a valuable reagent in the synthesis of biologically active small molecules. Its unique structure and properties make it a promising candidate for various applications in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
TERT-BUTYL 7-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE is used as a reagent for the preparation of biologically active small molecules. Its role in the synthesis of these molecules is crucial, as it can contribute to the development of new drugs and therapies for various medical conditions.
Used in Chemical Industry:
In the chemical industry, TERT-BUTYL 7-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE is utilized as a reagent for the synthesis of various chemical compounds. Its unique properties and reactivity make it a valuable component in the development of new materials and products with potential applications in various fields.

InChI:InChI=1/C14H19NO3/c1-14(2,3)18-13(17)15-7-6-10-4-5-12(16)8-11(10)9-15/h4-5,8,16H,6-7,9H2,1-3H3

Upstream product

• 30798-64-2 7-hydroxy-1,2,3,4-tetrahydroisoquinoline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 110192-19-3 7-hydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide 
• 39989-39-4 7-methoxyisoquinoline 
• 43207-78-9 7-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 591-31-1 3-methoxy-benzaldehyde 
• 7651-83-4 isoquinolin-7-ol 
• 1700-37-4 3-Benzyloxybenzaldehyde 
• 123-91-1 1,4-dioxane 
• 188576-56-9 1,2,3,4-tetrahydro-isoquinolin-7-ol acetate 
• 17680-55-6 7-bromo-1,2,3,4-tetrahydroisoquinoline 
• 258515-65-0 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylic acid tert-butyl ester 
• 937048-76-5 7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 94086-06-3 C₁₆H₁₇NO 

Downstream Products

• 188576-50-3 7-<(4-(benzyloxy)phenyl)(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 247132-98-5 benzyl 4-(2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)piperidin-1-carboxylate 
• 188576-51-4 7-<(ethoxycarbonyl)(4-hydroxyphenyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 218922-89-5 7-<(ethoxycarbonyl)<4-(tetrahydro-pyran-4-yloxy)phenyl>methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 218922-88-4 7-<<4-(1-acetylpiperidin-4-yloxy)phenyl>(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 188576-54-7 7-<<4-(1-(tert-butoxycarbonyl)pyrrolidin-3(S)-yloxy)phenyl>(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 218922-90-8 7-<<4-(1-(allyloxycarbonyl)pyrrolidin-3(S)-yloxy)phenyl>(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 218922-87-3 7-<<4-(1-(allyloxycarbonyl)piperidin-4-yloxy)phenyl>(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 188576-52-5 7-<<4-(1-(tert-butoxycarbonyl)piperidin-4-yloxy)phenyl>(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

MONOCYCLIC B-LACTAM COMPOUND FOR TREATING BACTERIAL INFECTION

Disclosed are a class of new monocyclic β-lactam compounds, an isomer thereof or pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the compounds, and the use of same in preparing drugs for treating diseases associated

DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS

The invention provides dihydroisoquinoline-2(1H)-carboxamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as cancer, and in inhibiting HPK1 activity.

Of tetracyclic Anaplastic lymphoma kinase inhibitors (by machine translation)

The invention belongs to the field of medical technology, in particular to general formula (I) as shown in of tetracyclic Anaplastic lymphoma kinase inhibitor, its pharmaceutically acceptable salt or a stereoisomer thereof, wherein R 1, R 2, R 3, R 4, R 5 and A link like defined in the specification. The invention also relates to methods of preparing such compounds, pharmaceutical preparations comprising these compounds and pharmaceutical composition, the compound and, its pharmaceutically acceptable salts or stereoisomers thereof, in the preparation of the treatment and/or prevention of Anaplastic lymphoma kinase-mediated cancer diseases related to the application of the medicament. (by machine translation)