110192-19-3

Basic information

• Product Name: 7-Isoquinolinol, 1,2,3,4-tetrahydro-, hydrobromide
• CAS NO: 110192-19-3
• Molecular Formula: C9H11NO.BrH
• Molecular Weight: 230.104
• Mol File: 110192-19-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 7-Isoquinolinol, 1,2,3,4-tetrahydro-, hydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Isoquinolinol, 1,2,3,4-tetrahydro-, hydrobromide(110192-19-3)
• EPA Substance Registry System: 7-Isoquinolinol, 1,2,3,4-tetrahydro-, hydrobromide(110192-19-3)

Safety Data

• Hazardous Substances Data: 110192-19-3(Hazardous Substances Data)

Usage

General Description

7-Isoquinolinol, 1,2,3,4-tetrahydro-, hydrobromide is a chemical compound that belongs to the class of isoquinolinol derivatives. It is commonly used as a reagent in organic synthesis and as a building block in the production of pharmaceuticals and agrochemicals. This chemical is also known for its potential pharmacological properties, including antihypertensive and antiarrhythmic effects. Additionally, it has been reported to have antioxidant and neuroprotective properties, making it of interest in the development of therapeutic agents for neurological disorders. The hydrobromide salt form of 7-Isoquinolinol, 1,2,3,4-tetrahydro- is commonly used to improve the solubility and stability of the compound, making it more suitable for various research and industrial applications.

Upstream product

• 39989-39-4 7-methoxyisoquinoline 
• 215453-91-1 tert-butyl 7-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1745-05-7 7-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 101033-24-3 4-methoxycinnamyl isocyanate 
• 34446-64-5 (E)-3-(4-methoxyphenyl)propenoyl chloride 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 16027-16-0 7-methoxy-2H-isoquinolin-1-one 
• 91247-71-1 2-4-methoxyphenylethylcarbamic acid methyl ester 
• 22246-04-4 7-methoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 591-31-1 3-methoxy-benzaldehyde 
• 43207-78-9 7-methoxy-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 247132-52-1 benzyl 7-(2-iodoethoxy)-1,2,3,4-tetrahydroisoquinolin-2-carboxylate 
• 247132-47-4 7-(4-ethoxycarbonylpiperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester 
• 247132-46-3 benzyl 7-(1-tert-butoxycarbonyl-4-ethoxycarbonylpiperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinolin-2-carboxylate 
• 247132-54-3 benzyl 7-[2-[4-ethoxycarbonyl-1-(pyridin-4-yl)piperidin-4-yl]ethoxy]-1,2,3,4-tetrahydroisoquinolin-2-carboxylate 
• 247132-50-9 benzyl 7-[1-(2-chloropyrimidin-4-yl)-4-ethoxycarbonylpiperidin-4-ylmethoxy]-1,2,3,4-tetrahydroisoquinolin-2-carboxylate 
• 247132-49-6 benzyl 7-[4-ethoxycarbonyl-1-(2-methylpyridin-4-yl)piperidin-4-ylmethoxy]-1,2,3,4-tetrahydroisoquinolin-2-carboxylate 
• 247132-53-2 benzyl 7-[2-(1-tert-butoxycarbonyl-4-ethoxycarbonylpiperidin-4-yl)ethoxy]-1,2,3,4-tetrahydroisoquinolin-2-carboxylate 
• 854261-77-1 benzyl 7-[1-(1-amidinophenyl-4-yl)-4-ethoxycarbonylpiperidin-4-ylmethoxy]-1,2,3,4-tetrahydroisoquinolin-2-carboxylate 
• 247132-42-9 7-chloromethoxy-3,4-dihydro-1H-isoquinolin-2-carboxylate benzyl ester 
• 247132-41-8 benzyl 7-methylthiomethoxy-1,2,3,4-tetrahydroisoquinolin-2-carboxylate 
• 247132-98-5 benzyl 4-(2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)piperidin-1-carboxylate 
• 832088-74-1 benzyl 7-[4-ethoxycarbonyl-1-(pyridin-4-yl)piperidin-4-ylmethoxy]-1,2,3,4-tetrahydroisoquinolin-2-carboxylate 
• 188576-49-0 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester 
• 854261-83-9 N,N'-di-tert-butoxycarbonyl-7-[1-(2-nitrophenylmethyl)piperidin-4-ylmethoxy]-1,2,3,4-tetrahydroisoquinolin-2-carboxamidine 

Relevant articles and documents

Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity

The dramatic increase in the prevalence of multi-drug resistant Gram-negative bacterial infections and the simultaneous lack of new classes of antibiotics is projected to result in approximately 10 million deaths per year by 2050. We report on efforts to target the Gram-negative ATP-binding cassette (ABC) transporter MsbA, an essential inner membrane protein that transports lipopolysaccharide from the inner leaflet to the periplasmic face of the inner membrane. We demonstrate the improvement of a high throughput screening hit into compounds with on-target single digit micromolar (μM) minimum inhibitory concentrations against wild-type uropathogenic Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae. A 2.98 ? resolution X-ray crystal structure of MsbA complexed with an inhibitor revealed a novel mechanism for inhibition of an ABC transporter. The identification of a fully encapsulated membrane binding site in Gram-negative bacteria led to unique physicochemical property requirements for wild-type activity.

Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring

A series of novel 2,7-disubstituted tetrahydroisoquinoline derivatives were designed and synthesized. Among these derivatives, compounds 1 and 2 exhibited potent inhibitory activity against factor Xa (FXa) and good selectivity with respect to other serine

Bronchorelaxing compounds

A compound of the general formula (I) including its pharmaceutically acceptable acid addition salts wherein A is CHR9, wherein R9 is H, C1-C6 alkyl; n is 1-3; B is CHR10, wherein R10 is H, C1-C6 alkyl; m is 1 or 2; D is O or S or optionally NR16, wherein R16 is H, C1-C6 alkyl or C2-C6 acyl; E is CR11R12 or NR13, wherein R11 and R12 are, independent of each other, H or C1-C6 alkyl, R13 is H or C1-C6 alkyl; F is C1-C18 alkyl which may be mono- or di-unsaturated and/or substituted, is useful in treating and preventing pulmonary disease characterized by bronchoconstriction. Also disclosed are pharmaceutical compositions comprising the compound and methods for their manufacture.