188656-16-8Relevant articles and documents
A Versatile Chemo-Enzymatic Route to Enantiomerically Pure β-Branched α-Amino Acids
Roff, Geoffrey J.,Lloyd, Richard C.,Turner, Nicholas J.
, p. 4098 - 4099 (2007/10/03)
A series of diastereoisomers of β-methyl-β-phenylalanine analogues 1a?f have been prepared in enantiomerically pure form using a combination of chemo- and biocatalysis. Starting from l-threonine methyl ester 2, a range of β,β-disubstituted didehydroamino
A convenient cross-coupling route to α,β,γ,δ-unsaturated amino acids
Burk, Mark J.,Allen, John G.,Kiesman, William F.,Stoffan, Karen M.
, p. 1309 - 1312 (2007/10/03)
β-Bromoenamide esters are coupled stereospecifically to vinylboronic acids via a palladium-catalyzed Suzuki reaction. This cross-coupling proceeds under mild conditions with Pd(OAc)2 in 95% EtOH at 50°C and produces amino acids with 1,3-diene side chains in high yields.
