188675-38-9Relevant articles and documents
Preparation of naphthoquinone derivatives from plumbagin and their ichthyotoxicity
Ogihara, Kazuhito,Yamashiro, Rieko,Higa, Matsutake,Yogi, Seiichi
, p. 437 - 445 (1997)
Various naphthoquinone derivatives were prepared from a natural product, 5-hydroxy-2-methyl-1,4-naphthoquinone (plumbagin); these were mostly substituted at C-3 through carbon-carbon bond formation mediated by a metal- based oxidant such as lead tetraacetate in the presence of various carboxylic acids. The halogenated compounds showed stronger ichthyotoxicity than plumbagin, but other derivatives were less active.