481-42-5Relevant articles and documents
EPI-ISOSHINANOLONE FROM PLUMBAGO SCANDENS
Bhattacharyya, J.,Carvalho, Vicente R. de
, p. 764 - 765 (1986)
Epi-isoshinanolone, a diastereomer of isoshinanolone, has been isolated from Plumbago scandens and characterized with the aid of NMR spectroscopy.Key Word Index - Plumbago scandens; Plumbaginaceae; epi-isoshinanolone; plumbagin; 13C NMR.
Dieterle,Kruta
, p. 457,461 (1936)
QUINONOID AND OTHER CONSTITUENTS OF ARISTEA ECKLONII
Kumar, Vijaya,Meepagala, Kumudini M.,Balasubramaniam, Sinnathamby
, p. 1118 - 1119 (1985)
Aristea ecklonii; Iridaceae; quinones; plumbagin; biplumbagin; neoisoshinanolone; sterols.Plumbagin, 3,3'-biplumbagin, 8,8'-biplumbagin, neoisoshinanolone and sitosterol were isolated from the leaves and rhizomes of Aristea ecklonii.The rhizomes also contained α-spinasterol.This is the first report of plumbagin, previously found in several dicotyledonous families, in a monocotyledon.
ISOLATION AND STRUCTURES OF DIOMUSCINONE AND DIOMUSCIPULONE FROM DIONAEA MUSCIPULA
Miyoshi, Eiichi,Shizuri, Yoshikazu,Yamamura, Shosuke
, p. 2385 - 2387 (1984)
From the fresh leaves and roots of Dionaea muscipula, two new substances (diomuscinone and diomuscipulone) have been isolated together with the known naphthoquinone plumbagin.The structures of the new compounds have been elucidated on the basis of their spectral data coupled with some chemical evidence. - Key Word Index: Dionaea muscipula; Droseraceae; phenolic compounds; diomuscinone; diomuscipulone.
1,4-Naphthoquinones, XXIV: On the dehalogenation of 2-/3-halogen-1,4-naphthoquinone derivatives
Wurm,Duchstein
, p. 193 - 195 (1995)
Bu3SnH is an effective reagent for the debromination of 2-bromonaphthoquinones but elimination of chlorine with 1c, e.g., only proceeds at 30%. With Et3SiH dechlorination does not occur at all. Instead, with the 5-acetoxy derivatives 1a/1d as starting materials the cyclic acetales 3a-c are formed as selectively protected juglone derivatives. The bromo derivative 3a is obtained only at temp. 10° and even at room temp. Br-Elimination occurs with low yield of 3b. An especially suitable reagent for the debromination of 1a-b leading to the natural compounds plumbagin (2a) and isoplumbagin (2b) is zinc-silver couple but Cl-elimination again occurs in traces only.
Enantioselective Nickel-Catalyzed Reductive Aryl/Alkenyl-Cyano Cyclization Coupling to All-Carbon Quaternary Stereocenters
Chen, Zi-Hao,Sun, Rui-Ze,Yao, Fei,Hu, Xu-Dong,Xiang, Long-Xue,Cong, Hengjiang,Liu, Wen-Bo
supporting information, p. 4776 - 4782 (2022/03/27)
An enantioselective nickel-catalyzed intramolecular reductive cross-coupling of C(sp2) electrophiles and cyano groups is reported. Enantioenriched CN-containing all-carbon quaternary stereocenters are assembled by desymmetrizing cyclization of aryl/alkeny
Highly Efficient Synthesis and Structure–Activity Relationships of a Small Library of Substituted 1,4-Naphthoquinones
Bao, Na,Ou, Jinfeng,Shi, Wei,Li, Na,Chen, Li,Sun, Jianbo
, p. 2254 - 2258 (2018/06/04)
A platform of highly efficient synthetic methodologies has been established to access a focused library of substituted 1,4-naphthoquinones derivatives functionalized with a diversity of amino/hydroxy/alkyl groups. Furthermore, the structure–activity relationship deduced from antiproliferative activities and toxicities of this 1,4-naphthoquinone library and intracellular reactive oxygen species (ROS) level detections might warrant future potential of plumbagin (2) and compound 13 as promising basic structures to develop novel anti-cancer agents.
New synthetic method of plumbagin
-
, (2017/08/31)
The invention discloses a new synthetic method of plumbagin (PL), and relates to the technical field of medicine and chemical industry. The plumbagin becomes a study hot spot in treating rheumatoid arthritis and other domains. In recent years, literatures report that the plumbagin also has the effects of preventing bacterial and fungal and is used for the study of anticancer and anti-AIDS infection. However, the extraction rate of nature plumbagin is low, and the profit space is small; besides, the reported synthetic method of plumbagin is low in overall yield, high in cost, and not easy to acquire the raw material reagent, complex in post treatment process, and not friendly for environment; moreover, the purification process involves in column chromatography for many times. The raw material for the synthetic method of plumbagin is low in price and easy to acquire, and environment-friendly; the post treatment and purification process are simple, the yield is greatly promoted, the industrial production can be realized; meanwhile, the method provides an important reference basis for the subsequent scientific and research work.