Welcome to LookChem.com Sign In|Join Free

CAS

  • or

188891-12-5

Post Buying Request

188891-12-5 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

188891-12-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 188891-12-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,8,9 and 1 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 188891-12:
(8*1)+(7*8)+(6*8)+(5*8)+(4*9)+(3*1)+(2*1)+(1*2)=195
195 % 10 = 5
So 188891-12-5 is a valid CAS Registry Number.

188891-12-5Relevant articles and documents

Light Control of Protein Solubility Through Isoelectric Point Modulation

Nadendla, Karthik,Friedman, Simon H.

, p. 17861 - 17869 (2017)

We previously described the photoactivated depot or PAD approach that allows for the light control of therapeutic protein release. This approach relies on the ability to use light to change a protein's solubility. Traditionally this was accomplished by li

Photoactivatable Prodrug of Doxazolidine Targeting Exosomes

Tamura, Ryo,Balabanova, Alla,Frakes, Samuel A.,Bargmann, Austin,Grimm, Jan,Koch, Tad H.,Yin, Hang

supporting information, p. 1959 - 1970 (2019/02/26)

Natural lipid nanocarriers, exosomes, carry cell-signaling materials such as DNA and RNA for intercellular communications. Exosomes derived from cancer cells contribute to the progression and metastasis of cancer cells by transferring oncogenic signaling molecules to neighboring and remote premetastatic sites. Therefore, applying the unique properties of exosomes for cancer therapy has been expected in science, medicine, and drug discovery fields. Herein, we report that an exosome-targeting prodrug system, designated MARCKS-ED-photodoxaz, could spatiotemporally control the activation of an exquisitely cytotoxic agent, doxazolidine (doxaz), with UV light. The MARCKS-ED peptide enters a cell by forming a complex with the exosomes in situ at its plasma membrane and in the media. MARCKS-ED-photodoxaz releases doxaz under near-UV irradiation to inhibit cell growth with low nanomolar IC50 values. The MARCKS-ED-photodoxaz system targeting exosomes and utilizing photochemistry will potentially provide a new approach for the treatment of cancer, especially for highly progressive and invasive metastatic cancers.

ANTHRACYCLINE PRODRUGS AND METHODS OF MAKING AND USING THE SAME

-

Page/Page column 34, (2016/11/17)

Therapeutically effective prodrug compounds for the prevention and treatment of cancer and pharmaceutical compositions containing these compounds as well as methods of making and using these compounds.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 188891-12-5