1889-84-5

Basic information

• Product Name: Ethanone, 2-hydroxy-2-(4-methoxyphenyl)-1-phenyl-
• CAS NO: 1889-84-5
• Molecular Formula: C15H14O3
• Molecular Weight: 242.274
• Mol File: 1889-84-5.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-hydroxy-2-(4-methoxyphenyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-hydroxy-2-(4-methoxyphenyl)-1-phenyl-(1889-84-5)
• EPA Substance Registry System: Ethanone, 2-hydroxy-2-(4-methoxyphenyl)-1-phenyl-(1889-84-5)

Safety Data

• Hazardous Substances Data: 1889-84-5(Hazardous Substances Data)

Usage

General Description

Ethanone, 2-hydroxy-2-(4-methoxyphenyl)-1-phenyl- is a chemical compound with the molecular formula C16H16O3. It is also known as 2-hydroxy-4'-methoxyacetophenone or 2-hydroxy-2'-methoxybenzophenone. Ethanone, 2-hydroxy-2-(4-methoxyphenyl)-1-phenyl- is a white to light yellow crystalline powder and is commonly used in the production of perfumes, pharmaceuticals, and UV absorbers. It is also used as a fragrance ingredient in cosmetics and personal care products. Additionally, it has potential applications in the development of medicinal and therapeutic products due to its pharmacological properties.

Upstream product

• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 536-74-3 phenylacetylene 
• 4254-17-5 4-methoxybenzoin 
• 100-52-7 benzaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 
• 5425-44-5 2-Phenyl-[1,3]dithiane 
• 5908-41-8 benzoyltrimethylsilane 
• 3277-27-8 diethyl benzoylphosphonate 
• 7664-93-9 sulfuric acid 
• 952018-01-8 α-amino-4'-methoxy-deoxybenzoin 
• 4842-39-1 R-(-)-1-(4-methoxyphenyl)-2-hydroxy-2-phenylethanone 
• 66985-48-6 2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetonitrile 
• 25438-37-3 phenyl(trimethylsiloxy)acetonitrile 
• 613-90-1 benzoyl cyanide 

Downstream Products

• 22711-21-3 4-methoxybenzil 
• 108791-38-4 2-acetoxy-1-(4-methoxyphenyl)-2-phenylethanone 
• 4254-17-5 4-methoxybenzoin 
• 122803-37-6 1-(4-Methoxy-phenyl)-2-phenyl-naphtho[2,1-b]furan 
• 16841-83-1 6-methoxy-3-(4-methoxyphenyl)-2-phenylbenzofuran 
• 55681-26-0 α,α-bis(4-methoxyphenyl)acetophenone 
• 144758-80-5 Bis(2-cyanoethyl) 1-(4-methoxyphenyl)-2-oxo-2-phenylethyl phosphate 
• 88648-94-6 1-phenyl-2-p-methoxyphenyl-2-chloroethanone 
• 38828-30-7 4-Methoxybenzoin benzoate 
• 24866-71-5 4-Methoxybenzoin-4-methoxybenzoate 
• 97059-86-4 4-methoxyphenyl-2-mercaptoimidazole 
• 25433-74-3 3-(4-methoxy-phenyl)-2-phenyl-benzofuran-6-ol 
• 100-09-4 4-methoxybenzoic acid 
• 65-85-0 benzoic acid 

Relevant articles and documents

Cross silyl benzoin additions catalyzed by lanthanum tricyanide

From a screen of (cyanide)metal complexes, an improved catalyst for the cross silyl benzoin addition was discovered. Several M(CN)3 complexes (M = Ce, Er, Sm, Y, Yb, La) were evaluated and lanthanum tricyanide was identified as the optimal cata

De Novo Synthesis of α-Hydroxy Ketones by Gallic Acid-Promoted Aerobic Coupling of Terminal Alkynes with Diazonium Salts

An unprecedented metal-free direct preparation of unprotected α-hydroxy ketones from terminal alkynes under mild conditions with diazonium salts as the arene source and without the requirement of irradiation is described. The process is general and fully compatible with a wide variety of substitution in both reactants. Experimental and computational evidence strongly suggest the involvement of radical species in the transformation.

Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors

A series of 4,5-diaryl-1H-imidazole-2(3H)-thione was synthesized and their inhibitory potency against soybean 15-lipoxygenase and free radical scavenging activities were determined. Compound 11 showed the best IC50 for 15-LOX inhibition (IC50 = 4.7 μM) and free radical scavenging activity (IC50 = 14 μM). Methylation of SH at C2 position of imidazole has dramatically decreased the 15-LOX inhibition and radical scavenging activity as it can be observed in the inactive compound 14 (IC50 >250 μM). Structure activity similarity (SAS) showed that the most important chemical modification in this series was methylation of SH group and Docking studies revealed a proper orientation for SH group towards Fe core of the 15-LOX active site. Therefore it was concluded that iron chelating could be a possible mechanism for enzyme inhibition in this series of compounds.