55681-26-0

Basic information

• Product Name: Ethanone, 2,2-bis(4-methoxyphenyl)-1-phenyl-
• CAS NO: 55681-26-0
• Molecular Formula: C22H20O3
• Molecular Weight: 332.399
• Mol File: 55681-26-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Ethanone, 2,2-bis(4-methoxyphenyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2,2-bis(4-methoxyphenyl)-1-phenyl-(55681-26-0)
• EPA Substance Registry System: Ethanone, 2,2-bis(4-methoxyphenyl)-1-phenyl-(55681-26-0)

Safety Data

• Hazardous Substances Data: 55681-26-0(Hazardous Substances Data)

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 98-86-2 acetophenone 
• 451-40-1 phenyl benzyl ketone 
• 100-66-3 methoxybenzene 
• 1218936-92-5 1-(4-methoxyphenyl)-2-oxo-2-phenylethyl dimethyl phosphate 
• 623-12-1 4-chloromethoxybenzene 
• 62573-86-8 N-benzoylbenzimidazole 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 69545-37-5 di(p-anisyl)methyl bromide 
• 7664-93-9 sulfuric acid 
• 5465-47-4 1,2-bis-(4-methoxy-phenyl)-1-phenyl-ethane-1,2-diol 
• 1889-84-5 4'-methoxybenzoin 
• 1074-12-0 phenylglyoxal hydrate 
• 6425-12-3 1-phenyl-2,2-dimorpholin-1-yl-ethanone 

Downstream Products

• 726-18-1 4,4'-dianisylmethane 
• 65-85-0 benzoic acid 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 872298-25-4 2,2-bis(4-methoxyphenyl)-1-phenylethan-1-ol 
• 859777-81-4 2,2-bis-(4-methoxy-phenyl)-1,1-diphenyl-ethanol 

Relevant articles and documents

Aqueous α-Arylation of Mono- and Diarylethanone Enolates at Low Catalyst Loading

Acetophenone and deoxybenzoin derivatives are selectively α-arylated using a combination of very small amounts of palladium acetate and diphenylphosphine oxide as catalyst system and water as the only solvent. Target di- and triarylethanones are isolated virtually free of metal residues, and the reaction is amenable to gram-scale. A mechanistic proposal based on TEM images, poisoning experiments, kinetic plot and ESI-MS spectrometry is also provided. (Figure presented.).

One-pot synthesis of diarylmethanones through palladium-catalyzed sequential coupling and aerobic oxidation of aryl bromides with acetophenone as a latent carbonyl donor

A one-pot palladium-catalyzed synthesis of symmetrical and unsymmetrical diarylmethanones using acetophenone and aryl bromides as raw materials has been developed. In this reaction, acetophenone acts as a latent carbonyl donor and two pathways of palladium-catalyzed sequential coupling and aerobic oxidation are identified. The reaction is applicable to a spectrum of substrates and delivers the products in moderate to good yields. This method can be used for the synthesis of ketoprofen, a nonsteroidal anti-inflammatory drug, in a two-step procedure and 45% overall yield.

Lewis acid-promoted friedel-crafts alkylation reactions with α-ketophosphate electrophiles

The BF3·OEt2-promoted nucleophilic substitution of α-aryl-α-ketophosphates to afford α,α-diaryl ketone products is described. Electron-rich α-ketophosphates perform best, with electron-neutral and electron-poor substrates also tolerated. The reaction is tolerant of a range of aromatic, heteroaromatic, and nonaromatic nucleophiles, with yields ranging from 44% to 84%. Enantioenriched starting material yields racemic product, suggesting an SN1 pathway via an acylcarbenium ion.