188922-45-4

Basic information

• Product Name: 2-(6-bromo-2,3-dimethoxyphenyl)-N-(3,4-methylenedioxyphenethyl)acetamide
• Synonyms: 2-(6-bromo-2,3-dimethoxyphenyl)-N-(3,4-methylenedioxyphenethyl)acetamide
• CAS NO: 188922-45-4
• Molecular Weight: 422.276
• Mol File: 188922-45-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(6-bromo-2,3-dimethoxyphenyl)-N-(3,4-methylenedioxyphenethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(6-bromo-2,3-dimethoxyphenyl)-N-(3,4-methylenedioxyphenethyl)acetamide(188922-45-4)
• EPA Substance Registry System: 2-(6-bromo-2,3-dimethoxyphenyl)-N-(3,4-methylenedioxyphenethyl)acetamide(188922-45-4)

Safety Data

• Hazardous Substances Data: 188922-45-4(Hazardous Substances Data)

Upstream product

• 1484-85-1 3,4-methylenedioxyphenylethylamine 
• 107290-26-6 2-(6-Bromo-2,3-dimethoxyphenyl)acetyl chloride 

Downstream Products

• 38826-42-5 oxocrebanine 
• 188922-51-2 1-(6-bromo-2,3-dimethoxybenzyl)-6,7-methylenedioxy-3,4-dihydroisoquinoline 
• 188922-54-5 5-[1-(6-Bromo-2,3-dimethoxy-phenyl)-meth-(Z)-ylidene]-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline-6-carboxylic acid ethyl ester 
• 77784-22-6 dehydrocrebanine 

Relevant articles and documents

The first total syntheses of (±)-norphoebine, dehydrophoebine, oxophoebine, dehydrocrebanine, oxocrebanine and uthongine and their cytotoxicity against three human cancer cell lines

The first total syntheses of (±)-norphoebine, dehydrophoebine, oxophoebine, dehydrocrebanine, oxocrebanine and uthongine have been achieved. The crucial step involved the formation of ring C by a microwave-assisted direct biaryl coupling to produce the aporphine skeleton in high yields. The synthetic alkaloids were evaluated for their cytotoxicity against three human cancer cell lines MCF7, KB and NCI-H187. The results showed that uthongine was the best candidate of the series and it exhibited cytotoxicity against a human breast cancer MCF7 line with an IC50?=?3.05?μM