188922-54-5

Basic information

• Product Name: 1,3-Dioxolo[4,5-g]isoquinoline-6(5H)-carboxylic acid, 5-[(6-bromo-2,3-dimethoxyphenyl)methylene]-7,8-dihydro-, ethyl ester, (Z)-
• CAS NO: 188922-54-5
• Molecular Formula: C22H22BrNO6
• Molecular Weight: 476.324
• Mol File: 188922-54-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolo[4,5-g]isoquinoline-6(5H)-carboxylic acid, 5-[(6-bromo-2,3-dimethoxyphenyl)methylene]-7,8-dihydro-, ethyl ester, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolo[4,5-g]isoquinoline-6(5H)-carboxylic acid, 5-[(6-bromo-2,3-dimethoxyphenyl)methylene]-7,8-dihydro-, ethyl ester, (Z)-(188922-54-5)
• EPA Substance Registry System: 1,3-Dioxolo[4,5-g]isoquinoline-6(5H)-carboxylic acid, 5-[(6-bromo-2,3-dimethoxyphenyl)methylene]-7,8-dihydro-, ethyl ester, (Z)-(188922-54-5)

Safety Data

• Hazardous Substances Data: 188922-54-5(Hazardous Substances Data)

Upstream product

• 188922-45-4 2-(6-bromo-2,3-dimethoxyphenyl)-N-(3,4-methylenedioxyphenethyl)acetamide 
• 107290-26-6 2-(6-Bromo-2,3-dimethoxyphenyl)acetyl chloride 
• 1484-85-1 3,4-methylenedioxyphenylethylamine 
• 541-41-3 chloroformic acid ethyl ester 
• 188922-51-2 1-(6-bromo-2,3-dimethoxybenzyl)-6,7-methylenedioxy-3,4-dihydroisoquinoline 

Downstream Products

• 77784-22-6 dehydrocrebanine 

Relevant articles and documents

Total synthesis of sinomendine and its analogs

Sinomendine (1), a good receptor antagonist of angiotensin II and rare oxoaporphine alkaloid isolated from traditional Chinese drug Sinomenium acutum (Thunb.) Rehd. et Wils, was synthesized from a bromobenzylidenetetrahydroisoquinolineenamide precursor (6). Photocyclization of this enamide led to a protected aporphine (7), which could be converted into oxoaporphine (9) and (±)-sinomendine (1) by Fremy's salt oxidation followed an available Grignard reaction.