189153-29-5

Basic information

• Product Name: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[S-[(4-chloro-2-pyridinyl)methyl] O-(2-cyanoethyl) phosphorothioate]
• CAS NO: 189153-29-5
• Molecular Formula: C40H40ClN4O9PS
• Molecular Weight: 819.272
• Mol File: 189153-29-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[S-[(4-chloro-2-pyridinyl)methyl] O-(2-cyanoethyl) phosphorothioate](CAS DataBase Reference)
• NIST Chemistry Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[S-[(4-chloro-2-pyridinyl)methyl] O-(2-cyanoethyl) phosphorothioate](189153-29-5)
• EPA Substance Registry System: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[S-[(4-chloro-2-pyridinyl)methyl] O-(2-cyanoethyl) phosphorothioate](189153-29-5)

Safety Data

• Hazardous Substances Data: 189153-29-5(Hazardous Substances Data)

Upstream product

• 10177-21-6 4-chloro-2-chloromethyl pyridine 
• 102987-83-7 5′-O-(4,4′-dimethoxytrityl)thymidine-3′-O-[2-cyanoethyl]phosphonate 
• 98796-51-1 5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] 

Downstream Products

• 189153-42-2 C₄₉H₅₁ClN₅O₁₄PS 

Relevant articles and documents

Solution phase synthesis of dithymidine phosphorothioate by a phosphotriester method using new S-protecting groups

A phosphotriester method for the synthesis of dithymidine phosphorothioates with eight S-protecting groups has been investigated. Three of the S-protecting groups possesed catalytic activity, however side reactions occurred under deprotection. The best S-protecting group was 4- chloro-2-nitrobenzyl which could be removed with a minimum of side reactions (0.3 %). The coupling reagent PyFNOP (11) gave protected dithymidine phosphorothioate in 96 % yield after 15 min coupling.