189215-90-5Relevant articles and documents
ARGINASE INHIBITORS AND METHODS OF USE THEREOF
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Page/Page column 97; 98, (2019/09/04)
Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase, wherein R1 is -NHR1a; R1a is -H or -C(O)CH(R1b)NHR1c; and R1b is selected from -H, -(C1-C4 ) alkyl and CH2OR1d and R1cis -H; or R1b and R1c, together with the atom to which they are attached, form a 5-membered heterocyclic ring; and R1d is H or -CH3.
Chimeric (aeg-pyrrolidine)PNAs: Synthesis and stereo-discriminative duplex binding with DNA/RNA
Lonkar, Pallavi S.,Ganesh, Krishna N.,Kumar, Vaijayanti A.
, p. 2604 - 2611 (2007/10/03)
The design and facile conversion of naturally occurring 4-hydroxyproline to all four diastereomers of thymine pyrrolidine PNA monomer, (2R,4S)-adenine, -guanine and -cytosine monomers and their incorporation into duplex forming PNA oligomers is reported,
Synthesis of new building blocks for peptide nucleic acids containing monomers with variations in the backbone
Jordan, Stephan,Schwemler, Christoph,Kosch, Winfried,Kretschmer, Axel,Schwenner, Eckhardt,Stropp, Udo,Mielke, Burkhard
, p. 681 - 686 (2007/10/03)
New PNA monomers containing aminoprolines or pyrrolidines as backbones have been synthesized. Oligomerisation was carried out on a solid support. Resistance to enzymatic degradation was tested.