19015-37-3

Basic information

• Product Name: 1-benzyl-4-phenylpiperidine
• CAS NO: 19015-37-3
• Molecular Formula: C₁₈H₂₁N
• Molecular Weight: 251.366
• Mol File: 19015-37-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 363.3°C at 760 mmHg
• Flash Point: 156.4°C
• Density: 1.047g/cm³
• Vapor Pressure: 1.83E-05mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 1-benzyl-4-phenylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-phenylpiperidine(19015-37-3)
• EPA Substance Registry System: 1-benzyl-4-phenylpiperidine(19015-37-3)

Safety Data

• Hazardous Substances Data: 19015-37-3(Hazardous Substances Data)

Usage

Classification

Synthetic stimulant with psychoactive properties

Structural similarity

Similar to amphetamine

Development

Developed as a recreational drug

Effects

Increased alertness, euphoria, and heightened energy levels

Legal status

Banned in several countries due to potential for abuse and negative health effects

Mechanism of action

Acts as a serotonin and dopamine reuptake inhibitor, leading to stimulant properties

Common presence

Found in "party pills"

Adverse effects

Insomnia, anxiety, and increased heart rate

Regulation

Production and distribution are strictly regulated in many jurisdictions due to potential for abuse and harmful effects.

Upstream product

• 62143-51-5 1-(phenylmethyl)-4-phenylpiperidin-2,6-dione 
• 873380-11-1 3-phenyl-glutaric acid bis-benzylamide 
• 71258-18-9 1-benzyl-4-phenyl-piperidine-4-carbonitrile; hydrochloride 
• 123-91-1 1,4-dioxane 
• 4165-96-2 3-phenylglutaric acid 
• 6768-26-9 2-phenyl-1,1,3,3-tetraethoxycarbonylpropane 
• 55951-74-1 diethyl 3-phenylpentanedioate 
• 4727-72-4 1-benzyl-4-hydroxypiperidine 
• 101768-14-3 1-benzyl-4-piperidinyl 4-methylbenzenesulfonate 
• 1493688-65-5 N-benzyl-4-(phenylthio)piperidine 
• 137059-25-7 N-benzyl-4-(phenylsulfonyl)piperidine 
• 100-58-3 phenylmagnesium bromide 
• 109838-88-2 1-benzyl-4-fluoropiperidine 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Downstream Products

• 113237-07-3 4-Phenyl-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester 
• 771-99-3 4-phenylpiperidine 
• 82902-54-3 phenyl(4-phenylpiperidin-1-yl)methanone 
• 1207280-46-3 1-benzyl-5,6-dihydro-4-phenylpyridin-2(1H)-one 

Relevant articles and documents

Palladium and Nickel Catalyzed Suzuki Cross-Coupling with Alkyl Fluorides

Suzuki cross-coupling of benzylic and unactivated aliphatic fluorides with aryl- and alkenylboronic acids has been achieved via mechanistically distinct Pd and Ni catalyzed pathways that outperform competing protodeboronation, β-hydride elimination, and h

Chiral cyclometalated iridium complexes for asymmetric reduction reactions

A series of chiral cyclometalated iridium complexes have been synthesised by cyclometalating chiral 2-aryl-oxazoline and imidazoline ligands with [Cp?IrCl2]2. These iridacycles were studied for asymmetric transfer hydrogenation reactions with formic acid as the hydrogen source and were found to display various activities and enantioselectivities, with the most effective ones affording up to 63% ee in the asymmetric reductive amination of ketones and 77% ee in the reduction of pyridinium ions. This journal is

Transition-Metal-Free Deconstructive Lactamization of Piperidines

One of the major challenges in organic synthesis is the activation or deconstructive functionalization of unreactive C(sp3)–C(sp3) bonds, which requires using transition or precious metal catalysts. We present here an alternative: the deconstructive lactamization of piperidines without using transition metal catalysts. To this end, we use 3-alkoxyamino-2-piperidones, which were prepared from piperidines through a dual C(sp3)–H oxidation, as transitory intermediates. Experimental and theoretical studies confirm that this unprecedented lactamization occurs in a tandem manner involving an oxidative deamination of 3-alkoxyamino-2-piperidones to 3-keto-2-piperidones, followed by a regioselective Baeyer–Villiger oxidation to give N-carboxyanhydride intermediates, which finally undergo a spontaneous and concerted decarboxylative intramolecular translactamization.