190275-58-2

Basic information

• Product Name: N-((4-fluorophenyl)sulfonyl)-L-valine N-hydroxysuccinimide ester
• Synonyms: N-((4-fluorophenyl)sulfonyl)-L-valine N-hydroxysuccinimide ester
• CAS NO: 190275-58-2
• Molecular Weight: 372.374
• Mol File: 190275-58-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-((4-fluorophenyl)sulfonyl)-L-valine N-hydroxysuccinimide ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-((4-fluorophenyl)sulfonyl)-L-valine N-hydroxysuccinimide ester(190275-58-2)
• EPA Substance Registry System: N-((4-fluorophenyl)sulfonyl)-L-valine N-hydroxysuccinimide ester(190275-58-2)

Safety Data

• Hazardous Substances Data: 190275-58-2(Hazardous Substances Data)

Upstream product

• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 72-18-4 L-valine 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 97801-48-4 (S)-2-(4-fluorobenzenesulfonylamino)-3-methylbutanoic acid 

Downstream Products

• 438003-82-8 (2S)-2-((4-fluorophenyl)sulfonylamino)-N-((1S)-1-(hydroxymethyl)-3-methylbutyl)-3-methylbutanamide 
• 605665-79-0 (3S)-N-butyl-3-((2S)-2-((4-fluorophenyl)sulfonylamino)-3-methylbutanoylamino)-2-hydroxy-5-methylhexanamide 
• 190274-53-4 N-((4-Fluorophenyl)sulfonyl)-L-valyl-L-leucinal 
• 605665-80-3 (2S)-2-((4-fluorophenyl)sulfonylamino)-3-methyl-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide 
• 502545-84-8 N-(4-fluorophenylsulfonyl)-L-valyl-L-tryptophanol 
• 502545-83-7 N-(4-fluorophenylsulfonyl)-L-valyl-L-phenylalaninol 
• 502545-85-9 N-(4-fluorophenylsulfonyl)-L-valyl-D-leucinol 
• 502545-86-0 N-(4-fluorophenylsulfonyl)-L-valyl-L-alaninol 

Relevant articles and documents

NOVEL ALPHA-KETOAMIDE DERIVATIVE AND USE THEREOF

The present invention provides a compound represented by the formula (I): wherein R1, R2 and R3 each represents a lower alkyl group.

Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor

Novel N-arylsulfonyldipeptidyl aldehyde derivatives were prepared by DMSO oxidation from the corresponding dipeptide alcohol, and their potencies as calpain inhibitors were evaluated in vitro. Among them, N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (8,