19056-83-8

Basic information

• Product Name: Propanedioic acid, [[(3-methylphenyl)amino]methylene]-, diethyl ester
• CAS NO: 19056-83-8
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.32
• Mol File: 19056-83-8.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [[(3-methylphenyl)amino]methylene]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [[(3-methylphenyl)amino]methylene]-, diethyl ester(19056-83-8)
• EPA Substance Registry System: Propanedioic acid, [[(3-methylphenyl)amino]methylene]-, diethyl ester(19056-83-8)

Safety Data

• Hazardous Substances Data: 19056-83-8(Hazardous Substances Data)

Upstream product

• 99-08-1 1-methyl-3-nitrobenzene 
• 105-53-3 diethyl malonate 
• 27971-92-2 diethyl 2,2,2-trichloroethylidenepropanedioate 
• 226881-93-2 2-(2,2,2-trichloro-1-m-tolylamino-ethyl)-malonic acid diethyl ester 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 108-44-1 1-amino-3-methylbenzene 

Downstream Products

• 41460-18-8 ethyl 4-hydroxy-7-methylquinoline-3-carboxylate 
• 50593-19-6 ethyl 4-chloro-7-methylquinoline-3-carboxylate 
• 51726-77-3 4-hydroxy-7-methylquinoline-3-carboxylic acid 
• 77721-00-7 ethyl 7-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 63136-61-8 4-chloro-7-methyl-quinoline 
• 82121-08-2 4-hydroxy-7-methylquinoline 
• 956485-77-1 C₃₉H₃₃NO₁₀ 
• 144181-61-3 2,2,2-trifluoro-N-(2-hydroxy-5-methylphenyl)acetamide 

Relevant articles and documents

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3-(Benzo[: D] thiazol-2-yl)-4-aminoquinoline derivatives as novel scaffold topoisomerase i inhibitor via DNA intercalation: Design, synthesis, and antitumor activities

Twenty-seven 3-(benzo[d]thiazol-2-yl)-4-aminoquinoline derivatives have been designed and synthesized as topoisomerase I inhibitors. The in vitro anti-proliferation evaluation against four human cancer cell lines (MGC-803, HepG-2, T24, and NCI-H460) and one normal cell line (HL-7702) indicated that most of them exhibited potent cytotoxicity. Among them, 5a was identified as the most promising candidate with a low IC50 value of about 2.20 ± 0.14 and was selected for further exploration. Spectroscopic analyses and agarose-gel electrophoresis assays indicated that 5a could interact with DNA and strongly inhibit topoisomerase I (Topo I). Further screening of the Topo I activity of compounds 5b, 5c, 5e, 5f, 5h, 5i, 5j, 5l, and 5n suggested that some of the compounds might exert quite a different cytotoxicity profile to that of 5a. Molecular modeling studies confirmed that 5a adopts a unique mode to interact with DNA and Topo I. Other molecular mechanistic studies suggested that the treatment of MGC-803 cells with 5a induces S phase arrest, up-regulates the pro-apoptotic protein, down-regulates the anti-apoptotic protein, activates caspase-3, and subsequently induces mitochondrial dysfunction so as to induce cell apoptosis. The in vivo efficiency of 5a was also evaluated on MGC-803 xenograft nude mice and the relative tumor growth inhibition was 42.4percent at 12 mg kg-1 without an obvious loss in the body weight. This journal is

Quinolone-Hydroxyquinoline Tautomerism in Quinolone 3-Esters. Preserving the 4-Oxoquinoline Structure To Retain Antimalarial Activity

Recent publications report in vitro activity of quinolone 3-esters against the bc1 protein complex of Plasmodium falciparum and the parasite. Docking studies performed in silico at the yeast Qo site established a key role for the 4-o