63136-61-8

Basic information

• Product Name: 4-CHLORO-7-METHOXYQUINOLINE
• Synonyms: 4-Chloro-7-methylquinoline
• CAS NO: 63136-61-8
• Molecular Formula: C₁₀H₈ClN
• Molecular Weight: 177.63
• Mol File: 63136-61-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 275.6°C at 760 mmHg
• Flash Point: 147°C
• Appearance: /
• Density: 1.225g/cm³
• Vapor Pressure: 0.00848mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 4-CHLORO-7-METHOXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-7-METHOXYQUINOLINE(63136-61-8)
• EPA Substance Registry System: 4-CHLORO-7-METHOXYQUINOLINE(63136-61-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 63136-61-8(Hazardous Substances Data)

Usage

Description

4-Chloro-7-methoxyquinoline is an organic compound with the chemical formula C10H8ClNO. It is a derivative of quinoline, a heterocyclic compound with a nitrogen atom in the ring structure. The presence of a chlorine atom at the 4-position and a methoxy group at the 7-position gives this compound unique chemical properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
4-Chloro-7-methoxyquinoline is used as a reagent in the synthesis of certain 4-aminoquinoline derivatives, which are employed as antimalarial agents. These derivatives have shown significant activity against malaria-causing parasites, making them valuable in the development of new treatments for this widespread disease.

InChI:InChI=1/C10H8ClN/c1-7-2-3-8-9(11)4-5-12-10(8)6-7/h2-6H,1H3

Upstream product

• 4053-43-4 7-methylquinoline N-oxide 
• 82121-08-2 4-hydroxy-7-methylquinoline 
• 25063-50-7 2,2-dimethyl-5-(m-tolylamino-methylene)-[1,3]dioxane-4,6-dione 
• 855871-26-0 8-chloro-7-methyl-quinolin-4-ol 
• 855764-51-1 8-chloro-4-hydroxy-7-methyl-quinoline-3-carboxylic acid 
• 6291-29-8 8-chloro-4-hydroxy-7-methyl-quinoline-3-carboxylic acid ethyl ester 
• 29027-17-6 2-chloro-3-methylaniline 
• 93919-55-2 7-methylquinolin-4(1H)-one 
• 77721-00-7 ethyl 7-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 108-44-1 1-amino-3-methylbenzene 
• 19056-83-8 diethyl 2-{[(3-methylphenyl)amino]methylene}propane-1,3-dioate 
• 41460-18-8 ethyl 4-hydroxy-7-methylquinoline-3-carboxylate 
• 51726-77-3 4-hydroxy-7-methylquinoline-3-carboxylic acid 

Downstream Products

• 5408-67-3 chloroquine 

Relevant articles and documents

Nitrogen-containing heterocyclic compound as well as preparation method, pharmaceutical composition and application thereof

The invention provides a nitrogen-containing heterocyclic compound as well as a preparation method, a pharmaceutical composition and application thereof, and particularly provides a compound as shownin a formula I which is described in the specification,

Novel Hepatitis C virus replicon inhibitors: Synthesis and structure-activity relationships of fused pyrimidine derivatives

The synthesis of several pyrido[2,3-d]pyrimidine and pyrimido[4,5-d] pyrimidine analogs is described with one such analog possessing subnanomolar potency in both genotype 1a and 1b cell culture HCV replicon assays.

Thioquinolone compounds which have useful pharmaceutical activity

Disclosed is a thioquinolone derivative which exhibits highly selective antibacterial activity against Helicobacter pylori.