190648-49-8 Usage
Description
Ro 32-3555 is an orally active collagenase inhibitor, which plays a crucial role in preventing cartilage breakdown. This pharmaceutical compound has been developed to target and inhibit the activity of collagenase enzymes, which are responsible for the degradation of collagen, a primary component of cartilage. By inhibiting these enzymes, Ro 32-3555 can help slow down the progression of cartilage damage and provide relief from the symptoms associated with arthritis.
Uses
Used in Pharmaceutical Industry:
Ro 32-3555 is used as a therapeutic agent for the treatment of arthritis. Its primary application is to inhibit the activity of collagenase enzymes, which are responsible for cartilage degradation. By preventing cartilage breakdown, Ro 32-3555 can help alleviate the pain, inflammation, and joint damage associated with arthritis, improving the quality of life for patients suffering from this condition.
In addition to its direct application in treating arthritis, Ro 32-3555 may also have potential uses in other industries, such as:
Used in Research and Development:
Ro 32-3555 can be utilized as a research tool to study the role of collagenase enzymes in cartilage degradation and the pathogenesis of arthritis. This can help scientists better understand the underlying mechanisms of the disease and develop new therapeutic strategies to combat it.
Used in Drug Delivery Systems:
Similar to gallotannin, Ro 32-3555 could potentially be incorporated into novel drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. These systems could include organic or metallic nanoparticles, liposomes, or other advanced drug delivery technologies, aiming to improve the efficacy and safety of Ro 32-3555 in treating arthritis and other related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 190648-49-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,0,6,4 and 8 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 190648-49:
(8*1)+(7*9)+(6*0)+(5*6)+(4*4)+(3*8)+(2*4)+(1*9)=158
158 % 10 = 8
So 190648-49-8 is a valid CAS Registry Number.
InChI:InChI=1/C22H36N4O5/c1-22(2)20(29)26(21(30)24(22)3)14-17(18(27)23-31)16(13-15-9-5-6-10-15)19(28)25-11-7-4-8-12-25/h15-17,31H,4-14H2,1-3H3,(H,23,27)/t16-,17+/m1/s1
190648-49-8Relevant articles and documents
Process for the preparation of hydroxamic acid derivatives
-
, (2008/06/13)
The present invention provides an improved process for preparing an hydroxycarbamoyl derivative of a carboxylic acid using a hydroxylammonium salt of a carboxylic acid as a reagent.
Practical approaches to the matrix metalloproteinase inhibitor Trocade (Ro 32-3555) and to the TNF-α converting enzyme inhibitor Ro 32-7315
Hilpert, Hans
, p. 7675 - 7683 (2007/10/03)
Stereoselective methods were found to efficiently prepare 2- and 3-substituted succinates with anti configuration. In the synthesis of Trocade 1, the hydantoinmethyl residue was introduced by alkylation of the non-chelated potassium enolate 19 with the br
Design and synthesis of the cartilage protective agent (CPA, Ro32-3555)
Broadhurst,Brown,Lawton,Ballantyne,Borkakoti,Bottomley,Cooper,Eatherton,Kilford,Malsher,Nixon,Lewis,Sutton,Johnson
, p. 2299 - 2302 (2007/10/03)
A novel series of MMP inhibitors has been identified. The compounds are potent selective inhibitors of collagenase with good solubility and oral bioavailability. One compound, designated Ro32-3555, has been selected for development as a cartilage protective agent for use in the treatment of rheumatoid- and osteoarthritis.
