19076-89-2

Basic information

• Product Name: (4-NITROPHENOXY) ACETIC ACID ETHYL ESTER
• Synonyms: (4-NITROPHENOXY) ACETIC ACID ETHYL ESTER;ethyl 2-(4-nitrophenoxy)acetate
• CAS NO: 19076-89-2
• Molecular Formula: C₁₀H₁₁NO₅
• Molecular Weight: 225.2
• EINECS: 242-883-7
• Mol File: 19076-89-2.mol
• Article Data: 43

Chemical Properties

• Melting Point: 78-80°
• Boiling Point: 349.5°Cat760mmHg
• Flash Point: 158.7°C
• Appearance: /
• Density: 1.263g/cm³
• Vapor Pressure: 4.7E-05mmHg at 25°C
• Refractive Index: 1.53
• CAS DataBase Reference: (4-NITROPHENOXY) ACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (4-NITROPHENOXY) ACETIC ACID ETHYL ESTER(19076-89-2)
• EPA Substance Registry System: (4-NITROPHENOXY) ACETIC ACID ETHYL ESTER(19076-89-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 19076-89-2(Hazardous Substances Data)

Usage

General Description

(4-Nitrophenoxy) acetic acid ethyl ester is a chemical compound with the formula C10H9NO5. It is a nitrophenyl ester of ethyl acetic acid, and it is primarily used as an intermediate in the production of other chemicals. (4-NITROPHENOXY) ACETIC ACID ETHYL ESTER has a yellowish appearance and is soluble in organic solvents. It is also known to have a strong odor. Due to its chemical properties, (4-Nitrophenoxy) acetic acid ethyl ester is commonly used in the manufacturing of pharmaceuticals, agrochemicals, and other industrial products. However, it is important to handle this compound with caution, as it may be harmful if ingested or if it comes into contact with the skin or eyes.

InChI:InChI=1/C10H11NO5/c1-2-15-10(12)7-16-9-5-3-8(4-6-9)11(13)14/h3-6H,2,7H2,1H3

Upstream product

• 64-17-5 ethanol 
• 1798-11-4 4-nitrophenoxyacetic acid 
• 100-02-7 4-nitro-phenol 
• 105-39-5 chloroacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 
• 824-78-2 4-nitrophenol sodium salt 
• 79-11-8 chloroacetic acid 

Downstream Products

• 75129-74-7 (4-nitro-phenoxy)-acetic acid hydrazide 
• 116977-17-4 2-(4-nitrophenoxy)acetohydroxamic acid 
• 19076-88-1 (4-nitro-phenoxy)-acetic acid-(2-diethylamino-ethylamide) 
• 58827-92-2 N-{2-[3-(2,3-Dihydro-benzo[1,4]dioxin-5-yloxy)-2-hydroxy-propylamino]-ethyl}-2-(4-nitro-phenoxy)-acetamide 
• 1798-11-4 4-nitrophenoxyacetic acid 
• 16365-27-8 2-(4-nitrophenoxy)ethanol 
• 20485-38-5 ethyl 2-(4-aminophenoxy)acetate 
• 72131-55-6 ethyl 2-{4-[(phenylsulfonyl)amino]phenoxy}acetate 
• 20142-88-5 2-(4-nitrophenoxy)acetyl chloride 
• 595605-86-0 2-[2-(4-amino-phenoxy)-acetylamino]-4,5-dimethoxy-benzoic acid ethyl ester 
• 595605-84-8 4,5-dimethoxy-2-[2-(4-nitro-phenoxy)-acetylamino]-benzoic acid ethyl ester 

Relevant articles and documents

Synthesis, molecular docking, dynamic simulation and pharmacological characterization of potent multifunctional agent (dual GPR40-PPARγ agonist) for the treatment of experimental type 2 diabetes

The current manuscript describes two molecules that were designed against PPARγ and GPR40 receptors. The preparation of the compounds was carried out following a synthetic route of multiple steps. Then, the mRNA expression levels of PPARγ, GLUT4, and GPR4

Synthesis, in vitro and in silico studies of a PPARγ and GLUT-4 modulator with hypoglycemic effect

Compound {4-[({4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetyl)amino]phenoxy}acetic acid (1) was prepared and the in vitro relative expression of PPARγ, GLUT-4 and PPARα, was estimated. Compound 1 showed an increase of 2-fold in the mRNA

Design and synthesis of α-phenoxy-N-sulfonylphenyl acetamides as Trypanosoma brucei Leucyl-tRNA synthetase inhibitors

Human African trypanosomiasis (HAT), caused by the parasitic protozoa Trypanosoma brucei, is one of the fatal diseases in tropical areas and current medicines are insufficient. Thus, development of new drugs for HAT is urgently needed. Leucyl-tRNA synthetase (LeuRS), a recently clinically validated antimicrobial target, is an attractive target for development of antitrypanosomal drugs. In this work, we report a series of α-phenoxy-N-sulfonylphenyl acetamides as T. brucei LeuRS inhibitors. The most potent compound 28g showed an IC50 of 0.70 μM which was 250-fold more potent than the starting hit compound 1. The structure-activity relationship was also discussed. These acetamides provided a new scaffold and lead compounds for the further development of clinically useful antitrypanosomal agents.

Synthesis and luminescence properties of novel 8-hydroxyquinoline derivatives and their Eu(III) complexes

Six novel 8-hydroxyquinoline derivatives were synthesized using 2-methyl-8-hydroxyquinoline and para-substituted phenol as the main starting materials, and were characterized by 1H nuclear magnetic resonance (NMR), mass spectrometry (MS), ultraviolet (UV) light analysis and infra-red (IR) light analysis. Their complexes with Eu(III) were also prepared and characterized by elemental analysis, molar conductivity, UV light analysis, IR light analysis, and thermogravimetric–differential thermal analysis (TG–DTA). The results showed that the ligand coordinated well with Eu(III) ions and had excellent thermal stability. The structure of the target complex was EuY1–6(NO3)3.2H2O. The luminescence properties of the target complexes were investigated, the results indicated that all target complexes had favorable luminescence properties and that the introduction of an electron-donating group could enhance the luminescence intensity of the corresponding complexes, but the addition of an electron-withdrawing group had the opposite effect. Among all the target complexes, the methoxy-substituted complex (–OCH3) had the highest fluorescence intensity and the nitro-substituted complex (–NO2) had the weakest fluorescence intensity. The results showed that 8-hydroxyquinoline derivatives had good energy transfer efficiency for the Eu(III) ion. All the target complexes had a relatively high fluorescence quantum yield. The fluorescence quantum yield of the complex EuY3(NO3)3.2H2O was highest among all target complexes and was up to 0.628. Because of excellent luminescence properties and thermal stabilities of the Eu(III) complexes, they could be used as promising candidate luminescent materials.