20485-38-5Relevant articles and documents
Synthesis, molecular docking, dynamic simulation and pharmacological characterization of potent multifunctional agent (dual GPR40-PPARγ agonist) for the treatment of experimental type 2 diabetes
Hidalgo-Figueroa, Sergio,Rodríguez-Luévano, Ana,Almanza-Pérez, Julio C.,Giacoman-Martínez, Abraham,Ortiz-Andrade, Rolffy,León-Rivera, Ismael,Navarrete-Vázquez, Gabriel
, (2021/06/18)
The current manuscript describes two molecules that were designed against PPARγ and GPR40 receptors. The preparation of the compounds was carried out following a synthetic route of multiple steps. Then, the mRNA expression levels of PPARγ, GLUT4, and GPR4
Pyrazolo[3,4-c]pyridine derivative
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Paragraph 0367; 0368; 0369, (2016/10/08)
The invention relates to a pyrazolo[3,4-c]pyridine derivative. The invention relates to a compound represented by a formula (I), a tautomer thereof, an optical isomer thereof or a pharmaceutically acceptable salt thereof, wherein the formula (I) is shown in the description, and Z, X, RNc, RNd, RNe and RNf are defined according to the claim 1. The invention further relates to the pharmaceutical composition contain the compound. The invention further relates to use of the compound or the pharmaceutical composition in preparing a drug for preventing and/or treating a disease which inhibits positive influence of an Xa factor, particularly use in preparing the drug for preventing and/or treating the disease which inhibits positive influence of the Xa factor under the condition of low hemorrhage risk.
HETEROARYL COMPOUNDS AND USES THEREOF
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Paragraph 0674, (2015/07/02)
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.