190839-76-0

Basic information

• Product Name: (2R)-tert-butyl-(2-azidomethyl-1-benzylethyl) carbamate
• Synonyms: (2R)-tert-butyl-(2-azidomethyl-1-benzylethyl) carbamate
• CAS NO: 190839-76-0
• Molecular Weight: 276.338
• Mol File: 190839-76-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: (2R)-tert-butyl-(2-azidomethyl-1-benzylethyl) carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-tert-butyl-(2-azidomethyl-1-benzylethyl) carbamate(190839-76-0)
• EPA Substance Registry System: (2R)-tert-butyl-(2-azidomethyl-1-benzylethyl) carbamate(190839-76-0)

Safety Data

• Hazardous Substances Data: 190839-76-0(Hazardous Substances Data)

Upstream product

• 126301-19-7 (2R)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropyl methanesulfonate 
• 18942-49-9 Boc-D-Phe-OH 
• 106454-69-7 N-tert-butoxycarbonyl-D-Phenylalaninol 
• 5267-64-1 (R)-2-amino-3-phenylpropanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 141595-88-2 (R)-tert-butyl (1-bromo-3-phenylpropan-2-yl)carbamate 

Downstream Products

• 85612-59-5 (R)-3-phenylpropane-1,2-diamine 
• 130406-33-6 (R)-α-(azidomethyl)-2-phenylethanamine 
• 185384-16-1 (2R)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropylamine 
• 1357194-37-6 (R)-1-azido-3-phenylpropan-2-amine hydrochloride 
• 185384-18-3 [(R)-1-Benzyl-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-ethyl]-carbamic acid tert-butyl ester 
• 714909-31-6 (S)-N¹-((R)-2-Amino-3-phenyl-propyl)-3-phenyl-propane-1,2-diamine 

Relevant articles and documents

PEPTIDE-OLIGOUREA HYBRID COMPOUNDS

The present description relates to peptidomimetic foldamers, and their synthesis. In particular, the description provides peptide-amino urea hybrid peptidomimetic foldamers comprising an alpha amino acid peptide portion and an oligourea portion.

Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors

Aminopeptidase N (APN), belonged to metalloproteinase, is an essential peptidase involved in the process of tumor invasion and metastasis. A series of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine were designed, synthesized and evaluate

Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping

Selective inhibition of neuronal nitric oxide synthase (nNOS) has been shown to prevent brain injury and is important for the treatment of various neurodegenerative disorders. This study shows that not only greater inhibitory potency and isozyme selectivity but more druglike properties can be achieved by fragment hopping. On the basis of the structure of lead molecule 6, fragment hopping effectively extracted the minimal pharmacophoric elements in the active site of nNOS for ligand hydrophobic and steric interactions and generated appropriate lipophilic fragments for lead optimization. More potent and selective inhibitors with better druglike properties were obtained within the design of 20 derivatives (compounds 7-26). Our structure - based inhibitor design for nNOS and SAR analysis reveal the robustness and efficiency of fragment hopping in lead discovery and structural optimization, which implicates a broad application of this approach to many other therapeutic targets for which known druglike small-molecule modulators are still limited.