191110-49-3

Basic information

• Product Name: 2-(benzyloxy)-5,7-diazaspiro[3.4]octane-6,8-dione
• Synonyms: 2-(benzyloxy)-5,7-diazaspiro[3.4]octane-6,8-dione
• CAS NO: 191110-49-3
• Molecular Weight: 246.266
• Mol File: 191110-49-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(benzyloxy)-5,7-diazaspiro[3.4]octane-6,8-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzyloxy)-5,7-diazaspiro[3.4]octane-6,8-dione(191110-49-3)
• EPA Substance Registry System: 2-(benzyloxy)-5,7-diazaspiro[3.4]octane-6,8-dione(191110-49-3)

Safety Data

• Hazardous Substances Data: 191110-49-3(Hazardous Substances Data)

Upstream product

• 30830-27-4 3-benzyloxy cyclobutanone 
• 506-87-6 ammonium carbonate 
• 191110-48-2 3-benzyloxycyclobutane-1,1-dicarboxamine 
• 100-39-0 benzyl bromide 
• 54166-15-3 diethyl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate 
• 54307-67-4 1-bromo-2-benzyloxy-3-chloropropane 

Downstream Products

• 222727-29-9 1-amino-3-benzyloxycyclobutane-1-carboxylic acid 
• 1035655-28-7 1-amino-3-(benzyloxy)cyclobutane-1-carboxylic acid ethyl ester 
• 413597-66-7 ethyl 3-(benzyloxy)-1-<<(tert-butyloxy)carbonyl>amino>cyclobutane-1-carboxylate 
• 413597-67-8 ethyl 1-<<(tert-butyloxy)carbonyl>amino>-3-hydroxycyclobutane-1-carboxylate 
• 1103448-30-1 (E)-2-benzyloxy-6,8-dioxo-5,7-diazaspiro[3,4]octane-5,7-dicarboxylic acid di-tert-butyl ester 
• 1103448-29-8 (Z)-2-benzyloxy-6,8-dioxo-5,7-diazaspiro[3,4]octane-5,7-dicarboxylic acid di-tert-butyl ester 
• 1103448-33-4 (E,Z)-2-benzyloxy-6,8-dioxo-5,7-diazaspiro[3,4]octane-5,7-dicarboxylic acid di-tert-butyl ester 
• 222727-33-5 1-t-butyl carbamate-3-benzyloxy-1-cyclobutane-1-carboxylic acid methyl ester 
• 222727-31-3 1-t-butyl carbamate-3-benzyloxy-1-cyclobutane-1-carboxylic acid 
• 222727-43-7 1-amino-3-fluorocyclobutane-1-carboxylic acid 

Relevant articles and documents

PROGRANULIN MODULATORS AND METHODS OF USING THE SAME

Provided herein are compounds of formula (I) that modulate progranulin and methods of using the compounds in progranulin- associated disorders, such as Frontotemperal lobe dementia (FTLD).

PROCESS SIMPLIFICATION FOR PRECURSOR COMPOUND

The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor useful in the preparation of the [18F]-1-amino-3- fluorocyclobutanecarboxyiic acid ([18F] FACBC) PET tracer.

Synthesis of [F-18]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC): A pet tracer for tumor delineation

Fluorine-18 labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC), a new tumor-avid amino acid, was synthesized for positron emission tomography. [18F]FACBC was prepared with high specific activity by nucleophilic displacement with an o