191655-54-6

Basic information

• Product Name: (R)-2-[(S)-3-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-tert-butoxycarbonylamino-propoxy]-propionic acid tert-butyl ester
• CAS NO: 191655-54-6
• Molecular Weight: 531.606
• Mol File: 191655-54-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-[(S)-3-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-tert-butoxycarbonylamino-propoxy]-propionic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-[(S)-3-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-tert-butoxycarbonylamino-propoxy]-propionic acid tert-butyl ester(191655-54-6)
• EPA Substance Registry System: (R)-2-[(S)-3-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-tert-butoxycarbonylamino-propoxy]-propionic acid tert-butyl ester(191655-54-6)

Safety Data

• Hazardous Substances Data: 191655-54-6(Hazardous Substances Data)

Upstream product

• 54631-38-8 (R)-tert-butyl 2-bromopropanoate 
• 79069-15-1 N-(tert-butyloxycarbonyl)-O-benzyl-L-serinol 
• 4330-20-5 N-3-benzoylthymine 
• 98104-35-9 tert-butyl S-α-bromopropionate 
• 23680-31-1 BOC-O-benzyl-L-serine 

Relevant articles and documents

Polyamide based nucleic acid analogs synthesis of δ-amino acids with nucleic acid bases bearing side chains

Nucleoamino acids of type I-III have been synthesized, which can serve as building blocks for novel polyamide based nucleic acid analogs. Key steps in the syntheses are the alkylation of serinol I and homoserinol 18 with tert-butyl bromoacetate or tert-butyl bromopropionate under phase transfer conditions and the introduction of thymine or uracil into the amino acid side drains by way of a Mitsunobu reaction. Cytosine derivatives were prepared through uracil → cytosine base conversion at the stage of N(δ)-BOC protected amino acid tert-butyl esters.