79069-15-1

Basic information

• Product Name: N-Boc-(S)-2-amino-3-benzyloxy-1-propanol
• Synonyms: BOC-O-BENZYL-D-SERINOL;BOC-O-BENZYL-L-SERINOL;BOC-D-SER(BZL)-OL;BOC-D-SERINOL(BZL);BOC-(S)-2-AMINO-3-PHENYLMETHOXY-1-PROPANOL;BOC-(R)-2-AMINO-3-PHENYLMETHOXY-1-PROPANOL;BOC-SERINOL(BZL);BOC-SER(BZL)-OL
• CAS NO: 79069-15-1
• Molecular Formula: C₁₅H₂₃NO₄
• Molecular Weight: 281.35
• Product Categories: Amino Acids;Amino Alcohols;Boc-Amino acid series
• Mol File: 79069-15-1.mol
• Article Data: 44

Chemical Properties

• Melting Point: 66-69 °C(lit.)
• Boiling Point: 443.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.105
• Storage Temp.: Store at 0-5°C
• PKA: 11.58±0.46(Predicted)
• CAS DataBase Reference: N-Boc-(S)-2-amino-3-benzyloxy-1-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-(S)-2-amino-3-benzyloxy-1-propanol(79069-15-1)
• EPA Substance Registry System: N-Boc-(S)-2-amino-3-benzyloxy-1-propanol(79069-15-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 79069-15-1(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white solid

Upstream product

• 23680-31-1 BOC-O-benzyl-L-serine 
• 66866-45-3 C₂₀H₂₉NO₇ 
• 80963-10-6 methyl O-benzyl-N-(tert-butoxycarbonyl)-L-serinate 
• 79069-54-8 (S)-2-(t-butoxycarbonylamino)-3-phenylmetoxy-1-propanal 
• 65559-43-5 N-tert-butoxycarbonyl-O-benzyl-L-serine pentafluorophenyl ester 
• 142285-65-2 3,5-diazido-1,6-di-O-benzyl-2,5-dideoxy-3,4-O-methylethylidene-L-iditol 
• 226931-87-9 1,6-di-O-benzyl-2,5-di-O-methanesulfonyl-3,4-O-methylethylidene-D-mannitol 
• 505084-92-4 (2S,3R,4R,5S)-2,5-Diazido-1,6-bis-benzyloxy-hexane-3,4-diol 
• 505085-04-1 (5-benzyloxy-1-benzyloxymethyl-4-tert-butoxycarbonylamino-2,3-dihydroxy-pentyl)-carbamic acid tert-butyl ester 
• 95715-85-8 2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester 
• 126181-46-2 (2R)-methyl 2-((tert-butoxycarbonyl)amino)-3-((tetrahydro-2H-pyran-2-yl)oxy)propanoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 4726-96-9 O-Benzyl-L-serine 
• 19525-87-2 O-methyl O-benzyl-L-serinate hydrochloride 

Downstream Products

• 127559-37-9 Succinic acid mono-((S)-3-benzyloxy-2-tert-butoxycarbonylamino-propyl) ester 
• 79069-54-8 (S)-2-(t-butoxycarbonylamino)-3-phenylmetoxy-1-propanal 
• 153782-93-5 (R)-2-Benzyloxymethyl-aziridine-1-carboxylic acid tert-butyl ester 
• 127407-54-9 (S)-2-t-butoxycarbonylamino-3-benzyloxy-1-methanesulfonyloxypropane 
• 137719-74-5 (S)-3-(benzyloxy)-2-<(tert-butoxycarbonyl)amino>propyl ethanethioate 
• 178761-48-3 (R)-2-t-butoxycarbonylamino-3-benzyloxy-1-methanesulfonyloxypropane 
• 183793-48-8 ((S)-2-Benzyloxy-1-methoxymethyl-ethyl)-carbamic acid tert-butyl ester 
• 179472-05-0 Isobutyric acid (S)-3-benzyloxy-2-tert-butoxycarbonylamino-propyl ester 
• 191655-29-5 (S)-(3-benzyloxy-2-t-butoxycarbonylaminopropoxy)acetic acid t-butyl ester 
• 191655-54-6 (R)-2-[(S)-3-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-tert-butoxycarbonylamino-propoxy]-propionic acid tert-butyl ester 
• 198417-68-4 (S)-4-Benzyloxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 179472-07-2 Isobutyric acid (R)-3-benzyloxy-2-tert-butoxycarbonylamino-propyl ester 
• 179472-12-9 1-O-benzyl-2-[(tert-butyloxycarbonyl)amino]-3-[N₃-benzoyl(thymin-1-yl)]-L-propanol 
• 350685-50-6 tert-butyl (R)-(1-(benzyloxy)-3-oxopropan-2-yl)carbamate 

Relevant articles and documents

Iterative Synthesis of Stereo- and Sequence-Defined Polymers via Acid-Orthogonal Deprotection Chemistry

Absolute control over polymer stereo- and sequence structure is highly challenging in polymer chemistry. Here, an acid-orthogonal deprotection strategy is proposed for the iterative synthesis of a family of unimolecular polymers starting with enantiopure

TRICYCLIC 2-QUINOLINONES AS ANTIBACTERIALS

This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof that are useful as antibacterial agents. The compounds are useful as inhibitors of bacterial gyrase activity and of bacterial infections, and have the structure of Formula (I): as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.

Synthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production

The piperazine heterocycle is broadly exploited in FDA-approved drugs and biologically active compounds, but its chemical diversity is usually limited to ring nitrogen substitutions, leaving the four carbon atoms underutilized. Using an efficient six-step synthesis, chiral amino acids were transformed into 3-substituted piperazine-2-acetic acid esters as diastereomeric mixtures whose cis and trans products (dr 0.56 a? 2.2:1, respectively) could be chromatographically separated. From five amino acids (both antipodes) was obtained a complete matrix of 20 monoprotected chiral 2,3-disubstituted piperazines, each as a single absolute stereoisomer, all but one in multigram quantities. In keeping with our overall purpose of constructing more Csp3-enriched compound libraries for drug discovery, these diverse and versatile piperazines can be functionalized on either nitrogen atom, allowing them to be used as scaffolds for parallel library synthesis and as intermediates for the production of novel piperazine compounds.