19198-87-9Relevant articles and documents
Evaluation of the metal-dependent cytotoxic behaviour of coordination compounds
Grau, Jordi,Renau, Cristina,Caballero, Ana B.,Caubet, Amparo,Pockaj, Marta,Lorenzo, Julia,Gamez, Patrick
, p. 4902 - 4908 (2018)
The [Cu(L)Cl2]2 and [Pt(L)Cl2] complexes were prepared from the simple Schiff-base ligand (E)-phenyl-N-((pyridin-2-yl)methylene)methanamine (L) and respectively, CuCl2 and cis-[PtCl2(DMSO)2]. DNA-interaction studies revealed that the copper complex most likely acts as a DNA cleaver whereas the platinum complex binds to the double helix. Remarkably, cell-viability experiments with HeLa, MCF7 and PC3 cells showed that [Cu(L)Cl2]2 is an efficient cytotoxic agent whereas [Pt(L)Cl2] is not toxic, illustrating the crucial role played by the nature of the metal ion in the corresponding biological activity.
Molybdenum (VI) Complexes Containing Pyridylimine Ligands: Effect of the Imine Nitrogen Substituent in the Epoxidation Reaction
Martínez-Martínez, Daniel,Santiago, M. León,Toscano, Rubén A.,Amézquita-Valencia, Manuel
, p. 243 - 251 (2021)
A series of pyridylimine ligands with variations of the substituent at the imine nitrogen were synthesized and coordinated to the [MoCl2O2] core. The novel molecular structures of the complexes were fully characterized by 1H and 13C NMR, FT-IR, ESI, EA, and X-ray crystallography, and their catalytic activity was studied for the epoxidation of alkenes using tert-butyl hydroperoxide (TBHP) as the oxidant. The new complexes showed excellent catalytic activity and fine selectivity in the epoxidation reaction compared with similar homogeneous molybdenum complexes. The results demonstrated that there is a significant change in the catalytic performance, depending on the alkyl arm on the structure of the pyridilimine ligand. The catalytic results indicated that complex [MoCl2O2(L)] (L: N-(2-Pyridinylmethylene)-1-tert-butylimine) C5 is the best catalytic precursor in the epoxidation of cyclohexene (TON: 92920 and TOF: 30974 h?1).
Hydrogen-Bond Catalysis of Imine Exchange in Dynamic Covalent Systems
Schaufelberger, Fredrik,Seigel, Karolina,Ramstr?m, Olof
supporting information, p. 15581 - 15588 (2020/10/02)
The reversibility of imine bonds has been exploited to great effect in the field of dynamic covalent chemistry, with applications such as preparation of functional systems, dynamic materials, molecular machines, and covalent organic frameworks. However, acid catalysis is commonly needed for efficient equilibration of imine mixtures. Herein, it is demonstrated that hydrogen bond donors such as thioureas and squaramides can catalyze the equilibration of dynamic imine systems under unprecedentedly mild conditions. Catalysis occurs in a range of solvents and in the presence of many sensitive additives, showing moderate to good rate accelerations for both imine metathesis and transimination with amines, hydrazines, and hydroxylamines. Furthermore, the catalyst proved simple to immobilize, introducing both reusability and extended control of the equilibration process.
Improving C=N bond reductions with (Cyclopentadienone)iron complexes: Scope and limitations
Cettolin, Mattia,Bai, Xishan,Lübken, Dennis,Gatti, Marco,Facchini, Sofia Vailati,Piarulli, Umberto,Pignataro, Luca,Gennari, Cesare
supporting information, p. 647 - 654 (2018/10/24)
Herein, we broaden the application scope of (cyclo-pentadienone)iron complexes 1 in C=N bond reduction. The catalytic scope of pre-catalyst 1b, which is more active than the “Kn?lker complex” (1a) and other members of its family, has been expanded to the catalytic transfer hydrogenation (CTH) of a wider range of aldimines and ketimines, either pre-isolated or generated in situ. The kinetics of 1b-promoted CTH of ketimine S1 were assessed, showing a pseudo-first order profile, with TOF = 6.07 h–1 at 50 % conversion. Moreover, the chiral complex 1c and its analog 1d were employed in the enantioselective reduction of ketimines and reductive amination of ketones, giving fair to good yields and moderate enantioselectivity.
