192124-88-2 Usage
Description
2,3-Dichloro-6-Nitrobenzyl Chloride is an organic compound characterized by its molecular structure that features a benzene ring with two chlorine atoms at the 2nd and 3rd positions, a nitro group at the 6th position, and a chlorine atom attached to the benzyl group. This chemical entity is known for its reactivity and is often utilized as an intermediate in the synthesis of various pharmaceuticals and organic compounds.
Uses
Used in Pharmaceutical Industry:
2,3-Dichloro-6-Nitrobenzyl Chloride is used as a chemical intermediate for the synthesis of Anagrelide (A637300), a phosphodiesterase inhibitor with antiplatelet activity. Anagrelide serves as an antithrombocythemic, which helps in managing thrombocytosis by reducing the production of platelets in the bone marrow.
Additionally, 2,3-Dichloro-6-Nitrobenzyl Chloride may be used as an impurity reference substance in the quality control and analysis of Anagrelide, ensuring the purity and safety of the final pharmaceutical product. This application is crucial for maintaining the efficacy and reliability of Anagrelide as a therapeutic agent in the treatment of thrombocytosis and related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 192124-88-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,1,2 and 4 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 192124-88:
(8*1)+(7*9)+(6*2)+(5*1)+(4*2)+(3*4)+(2*8)+(1*8)=132
132 % 10 = 2
So 192124-88-2 is a valid CAS Registry Number.
192124-88-2Relevant articles and documents
Method for the manufacture of anagrelide
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, (2008/06/13)
Methods are provided for making Anagrelide base from 2,3-dichlorobenzaldehyde. A method is also provided for making an intermediate compound ethyl N-(2,3-dichloro-6-nitrobenzyl)glycine from 2,3-dichlorobenzaldehyde and for reducing the glycine compound using either SnCl2 or a specially defined catalyst. A cyclization method to form Anagrelide base from the corresponding iminoquinazoline compound is further provided.
