70380-49-3

Basic information

• Product Name: 2,3-DICHLORO-6-NITROBENZYLAMINE
• Synonyms: RARECHEM AL BW 1287;2,3-DICHLORO-6-NITROBENZYLAMINE;2,3-Dichloro-6-nitro-benzeneMethanaMine;2,3-Dichloro-6-nitrobenzylamine hydrochloride;(2,3-dichloro-6-nitrophenyl)methanamine
• CAS NO: 70380-49-3
• Molecular Formula: C₇H₆Cl₂N₂O₂
• Molecular Weight: 221.04
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 70380-49-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 317.381°C at 760 mmHg
• Flash Point: 145.747°C
• Appearance: /
• Density: 1.523g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: 2-8°C(protect from light)
• Solubility: Ether
• PKA: 6.99±0.10(Predicted)
• CAS DataBase Reference: 2,3-DICHLORO-6-NITROBENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DICHLORO-6-NITROBENZYLAMINE(70380-49-3)
• EPA Substance Registry System: 2,3-DICHLORO-6-NITROBENZYLAMINE(70380-49-3)

Safety Data

• Hazardous Substances Data: 70380-49-3(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Intermediate in the preparation of Anagrelide.

InChI:InChI=1/C7H6Cl2N2O2/c8-5-1-2-6(11(12)13)4(3-10)7(5)9/h1-2H,3,10H2

Synthetic route

phthalimide (136918-14-4) + 1,2-dichloro-3-chloromethyl-4-nitrobenzene (192124-88-2) → 2,3-dichloro-6-nitrobenzylamine (70380-49-3)

2,3-dichloro-6-nitrobenzylamine (70380-49-3) + ethyl bromoacetate (105-36-2) → ethyl N-(2,3-dichloro-6-nitrobenzyl)glycine hydrochloride

Conditions	Yield
With triethylamine In 1,4-dioxane; ethanol

2,3-dichloro-6-nitrobenzylamine (70380-49-3) + ethyl bromoacetate (105-36-2) → N-(2,3-dichloro-6-nitrobenzyl)glycine ethyl ester hydrochloride (70380-50-6)

Conditions	Yield
Stage #1: 2,3-dichloro-6-nitrobenzylamine; ethyl bromoacetate With triethylamine In 1,4-dioxane at 90 - 100℃; for 4h; Stage #2: With hydrogenchloride In water; ethyl acetate; isopropyl alcohol at 20 - 30℃;

Upstream product

• 136918-14-4 phthalimide 
• 192124-88-2 1,2-dichloro-3-chloromethyl-4-nitrobenzene 

Downstream Products

• 70380-50-6 N-(2,3-dichloro-6-nitrobenzyl)glycine ethyl ester hydrochloride 

Relevant articles and documents

2-amino-5,6-dichloro-3,4-dihydroquinazoline, its method of making and using and pharmaceutical compositions thereof

The compound 2-amino-5,6-dichloro-3,4-dihydroquinazoline has been found to have enhanced platelet count reducing properties. Also provided are methods for synthetically making the compound and a method of reducing the platelet count in a patient by administering to the patient a platelet reducing effective amount of the compound preferably together with a pharmaceutically acceptable carrier. A pharmaceutical composition is also provided which contains the above compound as the active ingredient together with pharmaceutically acceptable excipients.