192570-33-5

Basic information

• Product Name: 5-Fluoroquinazoline-2,4(1H,3H)-dione
• Synonyms: 2,4(1H,3H)-Quinazolinedione, 5-fluoro-;5-Fluoroquinazoline-2,4(1H,3H)-dione;5-Fluoro-1H-quinazoline-2,4-dione;5-Fluoro-quinazoline-2,4-diol
• CAS NO: 192570-33-5
• Molecular Formula: C₈H₅FN₂O₂
• Molecular Weight: 180.1359032
• Mol File: 192570-33-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 320-322℃ (ethanol )
• Appearance: /
• Density: 1.434±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9?+-.0.20(Predicted)
• CAS DataBase Reference: 5-Fluoroquinazoline-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoroquinazoline-2,4(1H,3H)-dione(192570-33-5)
• EPA Substance Registry System: 5-Fluoroquinazoline-2,4(1H,3H)-dione(192570-33-5)

Safety Data

• Hazardous Substances Data: 192570-33-5(Hazardous Substances Data)

Usage

General Description

5-Fluoroquinazoline-2,4(1H,3H)-dione is a chemical compound with the molecular formula C8H4FN3O2. It belongs to the quinazoline-2,4-dione class of compounds and contains a fluorine atom attached to the quinazoline ring. This chemical has potential pharmacological properties and may be used in the development of drugs for various therapeutic purposes. Its precise applications and effects have not been extensively studied, but as a quinazoline derivative, it is likely to have biological activity and may exhibit interesting pharmacological properties. Further research is needed to fully understand the potential uses and effects of 5-Fluoroquinazoline-2,4(1H,3H)-dione.

Upstream product

• 434-76-4 2-amino-6-fluorobenzoic acid 
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Downstream Products

• 192570-36-8 1-(3,5-di-O-p-toluoyl-2-deoxy-α,β-D-erythro-pentofuranosyl)-5-fluoro-quinazoline-2,4(3H)-dione 
• 87611-00-5 2,4-dichloro-5-fluoroquinazoline 
• 769158-33-0 2-((2-chloro-5-fluoro-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile 
• 192570-56-2 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]-5-fluoro-quinazoline-2,4(3H)-dione 
• 192570-51-7 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-fluoro-quinazoline-2,4(3H)-dione 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF 1-(ARYLMETHYL)QUINAZOLINE-2,4(1H,3H)-DIONES

This disclosure provides a process for preparing 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones, specially provides a method for preparing the compound of Formula I, and the method comprises the step of reacting the compound of Formula II with the compound o

NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND ORGANIC ELECTROLUMINESCENCE DEVICES CONTAINING THEM

The present invention relates to compounds of the general formula (11), to a material for an organic electroluminescence device comprising ot least one of these compounds, to an organic electroluminescence device comprising at least one of these compounds

La-Mg mixed oxide as a highly basic water resistant catalyst for utilization of CO2 in the synthesis of quinazoline-2,4(1H,3H)-dione

The synthesis of quinazoline-2,4(1H,3H)-dione was done by direct utilization of CO2 in the cyclization of 2-aminobenzonitrile (2-ABN) using lanthanum magnesia mixed oxide (La-Mg MO) as a strong basic catalyst under mild reaction conditions in water. It gave a conversion of ～92% with 100% selectivity at 140 °C in 14 h. La-Mg MO was prepared by hydrothermal method using urea as homogeneous precipitating agent. The catalyst was characterized by different analytical techniques like BET, XRD, FT-IR, SEM, and TGA, and the basicity by CO2-TPD and acidity by NH3 TPD. Various reaction parameters were studied to predict the reaction mechanism and kinetics. The reaction follows the Langmuir-Hinshelwood-Hougen-Watson (LHHW) type kinetics model with an apparent activation energy of 23.3 kcal mol-1. The catalyst was recycled three times with an insignificant change in activity. The overall process is clean and green.