87611-00-5

Basic information

• Product Name: 2,4-DICHLORO-5-FLUOROQUINAZOLINE
• Synonyms: 2,4-DICHLORO-5-FLUOROQUINAZOLINE;4-dichloro-5-fluoroquinazoline
• CAS NO: 87611-00-5
• Molecular Formula: C₈H₃Cl₂FN₂
• Molecular Weight: 217.03
• Mol File: 87611-00-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 277.3±22.0 °C(Predicted)
• Appearance: /
• Density: 1.571±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.91±0.30(Predicted)
• CAS DataBase Reference: 2,4-DICHLORO-5-FLUOROQUINAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-5-FLUOROQUINAZOLINE(87611-00-5)
• EPA Substance Registry System: 2,4-DICHLORO-5-FLUOROQUINAZOLINE(87611-00-5)

Safety Data

• Hazardous Substances Data: 87611-00-5(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-5-fluoroquinazoline is a chemical compound that is a derivative of quinazoline. It features two chlorine atoms and one fluorine atom attached to the quinazoline ring. 2,4-Dichloro-5-fluoroquinazoline is widely used in the pharmaceutical industry for the synthesis of various drugs, especially as a building block for the development of anti-cancer and anti-inflammatory medications. It is also used as a reagent in organic synthesis and in the production of agricultural chemicals. Additionally, it has potential applications in the field of materials science and as a precursor for the creation of novel chemical compounds. Overall, 2,4-Dichloro-5-fluoroquinazoline has significant industrial and scientific value due to its diverse range of applications.

Upstream product

• 192570-33-5 5-fluoro-1H-quinazoline-2,4(1H,3H)-dione 
• 434-76-4 2-amino-6-fluorobenzoic acid 

Downstream Products

• 769158-33-0 2-((2-chloro-5-fluoro-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile 

Relevant articles and documents

NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND ORGANIC ELECTROLUMINESCENCE DEVICES CONTAINING THEM

The present invention relates to compounds of the general formula (11), to a material for an organic electroluminescence device comprising ot least one of these compounds, to an organic electroluminescence device comprising at least one of these compounds

Discovery of alogliptin: A potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV

Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4). Herein, we describe the structure-based design and optimization of alogliptin and related quinazolinone-based DPP-4 inhibitors. Following an oral dose, these noncovalent inhibitors provide sustained reduction of plasma DPP-4 activity and a lowering of blood glucose in animal models of diabetes. Alogliptin is currently undergoing phase 111 trials in patients with type 2 diabetes.