192725-73-8

Basic information

• Product Name: 3-(2,6-Dimethylphenyl)propionic acid
• Synonyms: 3-(2,6-DiMethylphenyl)propanoic Acid
• CAS NO: 192725-73-8
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178
• Product Categories: Aromatics;Intermediates
• Mol File: 192725-73-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(2,6-Dimethylphenyl)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,6-Dimethylphenyl)propionic acid(192725-73-8)
• EPA Substance Registry System: 3-(2,6-Dimethylphenyl)propionic acid(192725-73-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 192725-73-8(Hazardous Substances Data)

Usage

Description

3-(2,6-Dimethylphenyl)propionic acid is an organic compound characterized by its unique structure, featuring a propionic acid group attached to a 2,6-dimethylphenyl ring. This molecule is known for its potential applications in various fields, particularly in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
3-(2,6-Dimethylphenyl)propionic acid is used as a key intermediate in the synthesis of peptide analogs, specifically designed as retroviral protease inhibitors. These inhibitors play a crucial role in combating HIV infection by targeting the viral protease enzyme, which is essential for the replication of the virus. By inhibiting this enzyme, the synthesis of mature, infectious viral particles is disrupted, thereby helping to control the progression of HIV infection.

Upstream product

• 22768-06-5 methyl 3-(2',6'-dimethylphenyl)propionate 
• 527759-23-5 ethyl (E)-3-(2,6-dimethylphenyl)-2-propenoate 
• 1123-56-4 2,6-dimethylbenzaldehyde 
• 632-46-2 2,6-dimethylbenzoic acid 
• 62285-58-9 2,6-dimethylbenzyl alcohol 
• 100379-00-8 2,6-dimethylbenzene boronic acid 
• 79-10-7 acrylic acid 

Downstream Products

• 1449767-08-1 N-(5,6-dihydrothiazolo[2,3-c][1,2,4]triazol-3-yl)-3-(2,6-dimethylphenyl)propionamide 

Relevant articles and documents

Rhodium(I)-catalyzed 1,4-addition of arylboronic acids to acrylic acid in water: One-step preparation of 3-arylpropionic acids

A practical method for the one-step preparation of 3-arylpropionic acids through rhodium-catalyzed 1,4-addition of arylboronic acids to acrylic acid is reported. The method is applicable to a broad scope of aryl boronic acids and displays a wide functional group tolerance operating in water as the optimal reaction medium. Georg Thieme Verlag Stuttgart · New York.

Synthesis and structure-activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir)

The HIV protease inhibitor ABT-378 (Lopinavir) has a 2,6-dimethylphenoxyacetyl group in the P-2′ position. Analogues in which this group is replaced with various substituted phenyl or heteroaryl groups were synthesized and the structure-activity relationships explored.

RETROVIRAL PROTEASE INHIBITING COMPOUNDS

A compound of the formula: STR1 is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.