193006-24-5Relevant articles and documents
Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1
Quan, Mimi L.,Liauw, Ann Y.,Ellis, Christopher D.,Pruitt, James R.,Carini, David J.,Bostrom, Lori L.,Huang, Peggy P.,Harrison, Kimberly,Knabb, Robert M.,Thoolen, Martin J.,Wong, Pancras C.,Wexler, Ruth R.
, p. 2752 - 2759 (2007/10/03)
Thrombosis is a major cause of mortality in the industrialized world. Therefore, the prevention of blood coagulation has become a major target for new therapeutic agents. One attractive approach is the inhibition of factor Xa (FXa), the enzyme directly re
Bisbenzamidine isoxazoline derivatives as factor Xa inhibitors
Quan,Pruitt,Ellis,Liauw,Galemmo Jr.,Stouten,Wityak,Knabb,Thoolen,Wong,Wexler
, p. 2813 - 2818 (2007/10/03)
Factor Xa is an important serine protease in the blood coagulation cascade. It generates thrombin and holds the central position that links the intrinsic and extrinsic activation mechanism in the final common pathway of coagulation. Therefore, inhibition