19302-16-0Relevant articles and documents
Continuous Flow Chiral Amine Racemization Applied to Continuously Recirculating Dynamic Diastereomeric Crystallizations
Kwan, Maria H. T.,Breen, Jessica,Bowden, Martin,Conway, Louis,Crossley, Ben,Jones, Martin F.,Munday, Rachel,Pokar, Nisha P. B.,Screen, Thomas,Blacker, A. John
, p. 2458 - 2473 (2021/02/06)
A new, dynamic diastereomeric crystallization method has been developed, in which the mother liquors are continuously separated, racemized over a fixed-bed catalyst, and recirculated to the crystallizer in a resolution-racemization-recycle (R3) process. S
Imine reduction with me2s-bh3
Kamal, Mohammad M.,Liu, Zhizhou,Vidovi?, Dragoslav,Zhai, Siyuan
, (2021/09/13)
Although there exists a variety of different catalysts for hydroboration of organic substrates such as aldehydes, ketones, imines, nitriles etc., recent evidence suggests that tetra-coordinate borohydride species, formed by activation, redistribution, or decomposition of boron reagents, are the true hydride donors. We then proposed that Me2S-BH3 could also act as a hydride donor for the reduction of various imines, as similar compounds have been observed to reduce carbonyl substrates. This boron reagent was shown to be an effective and chemoselective hydroboration reagent for a wide variety of imines.
Transformation of N,N-diisopropylarylmethylamines into N-isopropylarylmethylamines with molecular iodine
Ezawa, Masatoshi,Moriyama, Katsuhiko,Togo, Hideo
, p. 6689 - 6692 (2016/02/03)
N,N-Diisopropylarylmethylamines were smoothly converted into the corresponding N-isopropylarylmethylamines by the reaction with molecular iodine in the presence of Na2CO3 in chloroform at 60 °C. Other related tertiary amines were also transformed into the corresponding secondary amines by the reaction with molecular iodine under the same reaction conditions.