1932-38-3

Basic information

• Product Name: Urea, N-phenyl-N'-propyl-
• CAS NO: 1932-38-3
• Molecular Formula: C10H14N2O
• Molecular Weight: 178.234
• Mol File: 1932-38-3.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Urea, N-phenyl-N'-propyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N-phenyl-N'-propyl-(1932-38-3)
• EPA Substance Registry System: Urea, N-phenyl-N'-propyl-(1932-38-3)

Safety Data

• Hazardous Substances Data: 1932-38-3(Hazardous Substances Data)

Upstream product

• 110-78-1 Propyl isocyanate 
• 62-53-3 aniline 
• 54680-33-0 propyl-carbamoyl azide 
• 107-10-8 propylamine 
• 6320-72-5 4-nitrophenyl-N-phenyl carbamate 
• 103-71-9 phenyl isocyanate 
• 96-49-1 [1,3]-dioxolan-2-one 
• 372-09-8 cyanoacetic acid 
• 108-86-1 bromobenzene 
• 201230-82-2 carbon monoxide 
• 591-50-4 iodobenzene 
• 50336-74-8 butyric acid azide 
• 98-95-3 nitrobenzene 
• 582-61-6 benzoyl azide 

Downstream Products

• 91467-19-5 1-phenyl-3-propyl-2,4,5-imidazolidinetrione 
• 117740-74-6 6-amino-5-nitroso-1-phenyl-3-n-propyl-2.4-(1H, 3H)-pyrimidinedione 
• 117740-75-7 5,6-diamino-1-phenyl-3-n-propyl-2,4-(1H, 3H)-pyrimidinedione 
• 176370-51-7 6-amino-1-phenyl-3-propylpyrimidine-2,4(1H,3H)-dione 
• 301206-14-4 1-(2-Cyano-acetyl)-3-phenyl-1-propyl-urea 

Relevant articles and documents

Synthesis method of substituted urea compound

The invention discloses a synthesis method of a substituted urea compound, which comprises the following steps: stirring aldehyde, N-aryl urea, trichlorosilane and Lewis base in an organic solvent ata temperature range of -20 DEG C to room temperature for

Direct conversion of carboxylic acids to various nitrogen-containing compounds in the one-pot exploiting curtius rearrangement

Herein we report, a single-pot multistep conversion of inactivated carboxylic acids to various N-containing compounds using a common synthetic methodology. The developed methodology rendered the use of carboxylic acids as a direct surrogate of primary amines, for the synthesis of primary ureas, secondary/tertiary ureas, O/S-carbamates, benzoyl ureas, amides, and N-formyls, exploiting the Curtius reaction. This approach has a potential to provide a diversified library of N-containing compounds, starting from a single carboxylic acid, based on the selection of the nucleophile.

2-Oxo-1,2-dihydropyridinyl-3-yl amide-based GPa inhibitors: Design, synthesis and structure-activity relationship study

Glycogen phosphorylase (GP), which plays a crucial role in the conversion of glycogen to glucose-1-phosphate, is a target for therapeutic intervention in diabetes. In this study, we report the design and synthesis of 29 new derivatives of 2-oxo-1,2-dihydro pyridin-3-yl amides, as potential inhibitors of GP. The hit rate (45%) was high with 13 compounds inhibiting GPa (between 33% at 4.40 mM and an IC50 of 1.92 μM). Two lead compounds were identified as compounds exhibiting good GPa inhibition (IC50 = 2.1 and 1.92 μM). SAR analysis of these compounds revealed sensitivity of GPa to the length of the 2-oxo-1,2-dihydro pyridin-3-yl amide derivative and a preference for inclusion of a 3,4-dichlorobenzyl moiety.