19367-33-0Relevant articles and documents
Ring-Opening of Isoxazolidine Nucleus by Trimethyl Phosphate Treatment: Formation of Tertiary Allylic Alcohols via Intermediate 1,3-Oxazinium Salts
Chiacchio, Ugo,Liguori, Angelo,Romeo, Giovanni,Sindona, Giovanni,Uccella, Nicola
, p. 799 - 817 (2007/10/02)
5,5-Disubstituted isoxazolidines undergo ring opening reaction, leading to tertiary allylic alcohols, by sequential treatment with trimethyl phosphate (TMP) and NaH.The reaction proceeds through sequence steps which involve an initial alkylation to isoxaz