194034-43-0Relevant articles and documents
Suntheses of (3S)-3-hydroxy-2-pyrrolidinone from (S)-malic acid
Pires, Raul,Burger, Klaus
, p. 9213 - 9218 (1997)
(S)-Malic acid 2 is transformed into (3S)-3-hydroxy-2-pyrrolidinone (8) using hexafluoroacotone os protecting and activating agent. Two alternative routes were developed; key step of both routes is the intramolecular aminolytic cleavage of the lactone rin
Orthogonally protected, carboxy-activated L-homoisoserine, 2-methyl-L-homoisoserine, and homoisocysteine derivatives. New building blocks for peptide and depsipeptide modification
Burger, Klaus,Radics, Gabor,Hennig, Lothar,Boettcher, Christoph,Spengler, Jan,Albericio, Fernando
, p. 763 - 776 (2007/10/03)
Starting from L-malic, L-citramalic, and rac. thiomalic acids routes to L-homoisoserine, 2-methyl-L-homoisoserine and rac. homoisocysteine have been developed. The new orthogonally protected and carboxy-activated building blocks are GABA as well as α-hydr