34368-52-0

Basic information

• Product Name: (S)-3-HYDROXY-PYRROLIDIN-2-ONE
• Synonyms: (S)-3-Hydroxypyrrolidine-2-one;(S)-3-Hydroxypyrrolidin-2-one;(3S)-3-hydroxypyrrolidin-2-one;(S)-3-Hydroxy-2-pyrrolidone 97%,EE97%;2-Pyrrolidinone, 3-hydroxy-, (3S)-;(S)-3-Hydroxy-ydroxy-pyrrolidin-2-one;(S)-3-Hydroxypyrrolidin-2-one, 95+%;(S)-3-Hydroxy-Pyrrolidin-2-One(WX642165)
• CAS NO: 34368-52-0
• Molecular Formula: C₄H₇NO₂
• Molecular Weight: 101.1
• EINECS: 1308068-626-2
• Mol File: 34368-52-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 100-102 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
• Boiling Point: 363.637 °C at 760 mmHg
• Flash Point: 173.722 °C
• Appearance: /
• Density: 1.292 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Sparingly)
• PKA: 12.82±0.20(Predicted)
• CAS DataBase Reference: (S)-3-HYDROXY-PYRROLIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-HYDROXY-PYRROLIDIN-2-ONE(34368-52-0)
• EPA Substance Registry System: (S)-3-HYDROXY-PYRROLIDIN-2-ONE(34368-52-0)

Safety Data

• Hazardous Substances Data: 34368-52-0(Hazardous Substances Data)

Usage

General Description

(S)-3-Hydroxy-pyrrolidin-2-one, also known as (S)-lactam, is a chemical compound with a molecular formula of C5H9NO2. It is a chiral lactam, which means it exists in two enantiomeric forms, with the (S)-enantiomer being the biologically active form. (S)-3-Hydroxy-pyrrolidin-2-one is used in various pharmaceutical and agricultural applications, including as a building block for the synthesis of pharmaceutical compounds and as a chiral auxiliary in asymmetric catalysis. It is also used as a precursor in the production of herbicides and fungicides. (S)-3-HYDROXY-PYRROLIDIN-2-ONE has shown potential as an anti-inflammatory and anti-tumor agent, and its various applications make it a valuable chemical in the fields of medicine and agriculture.

InChI:InChI=1/C4H7NO2/c6-3-1-2-5-4(3)7/h3,6H,1-2H2,(H,5,7)/t3-/m0/s1

Upstream product

• 3938-83-8 (S)-4-amino-2-hydroxybutanoic acid 
• 111466-53-6 (S)-3-((trimethylsilyl)oxy)pyrrolidin-2-one 
• 194034-36-1 ((S)-5-Oxo-2,2-bis-trifluoromethyl-[1,3]dioxolan-4-yl)-acetonitrile 
• 194034-43-0 (5S)-5-[2-(benzyloxycarbonylamino)ethyl]-2,2-bis(trifluoromethyl)-1,3-dioxolan-4-one 
• 630127-11-6 (S)-4-azido-2-hydroxybutyric acid ethyl ester 

Downstream Products

• 130403-91-7 (3S)-3-[tert-butyl(dimethyl)silyl]oxypyrrolidin-2-one 
• 259264-78-3 (S)-3-[(tert-butylbis(4-methylphenyl)silyl)oxy]pyrrolidin-2-one 
• 259264-58-9 (S)-(-)-3-[(tert-butyldiphenylsilyl)oxy]pyrrolidin-2-one 
• 332135-05-4 2-benzyl-3-methoxymethyloxy-6-[(3S)-3-hydroxy-2-pyrrolidinone-1-yl]pyridine 
• 100243-39-8 3-hydroxypyrrolidine 
• 1228468-93-6 (S)-1-benzyl-3-(benzyloxy)pyrrolidin-2-one 
• 77510-50-0 (3R)-3-hydroxy-2-pyrrolidinone 
• 1263404-03-0 (R)-(+)-methyl 3-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)-5-((2-oxopyrrolidin-3-yl)oxy)benzoate 
• 1398744-12-1 (3S)-3-hydroxy-1-(3-methylphenyl)pyrrolidin-2-one 
• 1593701-28-0 (R)-3-[6-(4-fluorophenoxy)pyridin-3-yloxy]pyrrolidin-2-one 

Relevant articles and documents

Total Synthesis of Plusbacin A3 and Its Dideoxy Derivative Using a Solvent-Dependent Diastereodivergent Joullié-Ugi Three-Component Reaction

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