194736-83-9

Basic information

• Product Name: D-N-Me-Phe-FDAA
• Synonyms: D-N-Me-Phe-FDAA
• CAS NO: 194736-83-9
• Molecular Weight: 431.405
• Mol File: 194736-83-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: D-N-Me-Phe-FDAA(CAS DataBase Reference)
• NIST Chemistry Reference: D-N-Me-Phe-FDAA(194736-83-9)
• EPA Substance Registry System: D-N-Me-Phe-FDAA(194736-83-9)

Safety Data

• Hazardous Substances Data: 194736-83-9(Hazardous Substances Data)

Upstream product

• 1255709-51-3 7,39-epi-Lagunamide A 
• 95713-52-3 N-(2,4-dinitro-5-fluorophenyl)-L-alaninamide 
• 1255709-52-4 lagunamide B 
• 95713-52-3 (1-fluoro-2,4-dinitrophenyl)-5-L-alanine amide 
• 56564-52-4 N-methyl-D-phenylalanine 
• 1362040-53-6 symplocin A 
• 18942-49-9 Boc-D-Phe-OH 
• 37553-65-4 N-tert-butoxycarbonyl-N-methyl-D-phenylalanine 

Relevant articles and documents

Total synthesis and pharmacological investigation of cordyheptapeptide A

The present investigation reports the synthesis of a phenylalanine-rich N-methylated cyclopeptide, cordyheptapeptide A (8), previously isolated from the insect pathogenic fungus Cordyceps sp. BCC 1788, accomplished through the coupling of N-methylated tetrapeptide and tripeptide fragments followed by cyclization of the linear heptapeptide unit. Structure elucidation of the newly synthesized cyclopolypeptide was performed by means of FT-IR, 1H-NMR, 13C-NMR, and fast atom bombardment mass spectrometry (FABMS), and screened for its antibacterial, antidermatophytic, and cytotoxic potential. According to the antimicrobial activity results, the newly synthesized N-Methylated cyclopeptide exhibited potent antibacterial activity against Gram-negative bacteria Pseudomonas aeruginosa and Klebsiella pneumoniae and antifungal activity against dermatophytes Trichophyton mentagrophytes and Microsporum audouinii at a concentration of 6μg/mL, in comparison to the reference drugs, gatifloxacin and griseofulvin. In addition, cyclopolypeptide 8 displayed suitable levels of cytotoxicity against Dalton's lymphoma ascites (DLA) and Ehrlich's ascites carcinoma (EAC) cell lines.

Identification of an Anti-MRSA Cyclic Lipodepsipeptide, WBP-29479A1, by Genome Mining of Lysobacter antibioticus

Lysobacter are ubiquitous in the environment but remain largely underexplored, although the bacteria are considered "peptide specialists". Here, we identified a new cyclic lipodepsipeptide, WBP-29479A1 (1), through genome mining of L. antibioticus ATCC 29479. 1 is biosynthesized by a large NRPS gene cluster, and its structure, including the six nonproteinogenic residues and 3-hydroxy fatty acid, was determined by extensive spectroscopic analyses and chemical derivatization. 1 exhibits potent anti-MRSA activity in a menaquinone-dependent manner.

Eight linear peptides from the deep-sea-derived fungus Simplicillium obclavatum EIODSF 020

Eight new linear peptides, simplicilliumtides A-H (1-8) were isolated from a culture broth of the deep-sea-derived fungal strain Simplicillium obclavatum EIODSF 020. Their structures were elucidated by spectroscopic analysis, and their absolute configurat