194788-06-2

Basic information

• Product Name: CyclobutaneMethanol, 3-[4-aMino-5-[3-(phenylMethoxy)phenyl]-7H-pyrrolo[2,3-d]pyriMidin-7-yl]-, trans-
• Synonyms: CyclobutaneMethanol, 3-[4-aMino-5-[3-(phenylMethoxy)phenyl]-7H-pyrrolo[2,3-d]pyriMidin-7-yl]-, trans-;(trans-3-(4-Amino-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclobutyl)methanol
• CAS NO: 194788-06-2
• Molecular Formula: C24H24N4O2
• Molecular Weight: 400.47296
• Mol File: 194788-06-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: CyclobutaneMethanol, 3-[4-aMino-5-[3-(phenylMethoxy)phenyl]-7H-pyrrolo[2,3-d]pyriMidin-7-yl]-, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: CyclobutaneMethanol, 3-[4-aMino-5-[3-(phenylMethoxy)phenyl]-7H-pyrrolo[2,3-d]pyriMidin-7-yl]-, trans-(194788-06-2)
• EPA Substance Registry System: CyclobutaneMethanol, 3-[4-aMino-5-[3-(phenylMethoxy)phenyl]-7H-pyrrolo[2,3-d]pyriMidin-7-yl]-, trans-(194788-06-2)

Safety Data

• Hazardous Substances Data: 194788-06-2(Hazardous Substances Data)

Upstream product

• 952138-97-5 2-amino-1-[cis-3-(hydroxymethyl)cyclobutyl]-4-[3-(phenylmethoxy)phenyl]-1H-pyrrole-3-carbonitrile 
• 3473-63-0 formamidine acetic acid 
• 121-71-1 3-Hydroxyacetophenone 
• 100-39-0 benzyl bromide 
• 34068-01-4 1-[3-(phenylmethoxy)phenyl]ethan-1-one 
• 115852-00-1 N-<2-(3-benzyloxyphenyl)-2-oxoethyl>acetamide 
• 194787-36-5 5-(3-benzyloxy-phenyl)-7H-pyrrolo [2,3-d] pyrimidin-4-ylamine 
• 19381-40-9 1-(3-(benzyloxy)phenyl)-2-bromoethanone 
• 54166-15-3 diethyl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate 
• 4958-02-5 3-(benzyloxy)cyclobutane-1-carboxylic acid 
• 4934-98-9 methylester of 3-benzyloxycyclobutane-1-carboxylic acid 
• 4934-99-0 methylester of 3-hydroxycyclobutane-1-carboxylic acid 

Downstream Products

• 475488-34-7 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]-pyrimidin-4-amine 

Relevant articles and documents

A concise synthesis of a novel insulin-like growth factor i receptor (IGF-IR) inhibitor

An efficient synthesis of a potent insulin-like growth factor I receptor (IGF-IR) inhibitor AEW541 (1) is described. The key step in the synthesis is the cis-selective reductive animation of cyclobutanone, which sets up the desired 1,3-stereochemistry of the cyclobutane ring. The amino group thus generated is used as a handle to build the pyrrolopyrimidine ring. The final step resulting in 1 is accomplished by alkylation of in situ generated mesylate with azetidine.