19486-73-8

Basic information

• Product Name: N-tert-Butyl-4-methoxybenzamide
• Synonyms: N-(1,1-Dimethylethyl)-4-methoxybenzamide;N-tert-Butyl-4-methoxybenzamide;N-tert-Butyl-p-anisamide;N-tert-Butyl-p-methoxybenzamide
• CAS NO: 19486-73-8
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.27
• Mol File: 19486-73-8.mol
• Article Data: 76

Chemical Properties

• Melting Point: 114-116 °C
• Boiling Point: 346.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.019±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• PKA: 15.11±0.46(Predicted)
• CAS DataBase Reference: N-tert-Butyl-4-methoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-Butyl-4-methoxybenzamide(19486-73-8)
• EPA Substance Registry System: N-tert-Butyl-4-methoxybenzamide(19486-73-8)

Safety Data

• Hazardous Substances Data: 19486-73-8(Hazardous Substances Data)

Usage

General Description

N-tert-Butyl-4-methoxybenzamide is an organic chemical compound with the molecular formula C13H19NO2. It is a white to off-white powder that is commonly used in the synthesis of pharmaceuticals and agrochemicals. N-tert-Butyl-4-methoxybenzamide is a derivative of 4-methoxybenzamide, with a tert-butyl group attached to the nitrogen atom. It is also known for its use in the development of novel materials and as a reagent in organic chemical reactions. N-tert-Butyl-4-methoxybenzamide is considered to be a stable and non-hazardous chemical when handled and used in accordance with proper safety protocols.

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 75-64-9 tert-butylamine 
• 43052-01-3 2-tert-butyl-3-(4-methoxyphenyl)-1,2-oxaziridine 
• 15875-74-8 N-(4-methoxybenzylidene)-2-methylpropan-2-amine 
• 82079-47-8 (E)-2-(tert-butyl)-3-(4-methoxyphenyl)oxarizidine 
• 15875-74-8 (E)-tert-butyl[(4-methoxyphenyl)methylidene]amine 
• 133587-76-5 4-tert-Butyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1,2,4-oxadiazole 
• 540-88-5 acetic acid tert-butyl ester 
• 874-90-8 4-methoxybenzonitrile 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 201230-82-2 carbon monoxide 
• 937-29-1 4-methoxybenzoyl bromide 
• 75-65-0 tert-butyl alcohol 
• 696-62-8 para-iodoanisole 

Downstream Products

• 136546-48-0 N-tert-Butyl-4-methoxy-2-methylsulfanyl-benzamide 
• 153967-89-6 4-methoxy-2,N-dimethyl-benzamide 
• 335596-32-2 N-(tert-butyl)-4-methoxy-2-methylbenzamide 
• 3424-93-9 4-methoxyphenylacetamide 
• 335596-12-8 N-benzyl-N-tert-butyl-4-methoxy-2-methylbenzamide 
• 136546-51-5 N-(1,1-dimethylethyl)-4-methoxy-2-(methylsulfinyl)benzamide 
• 100654-58-8 (C₆H₄(OCH₃)C(O)NH(C(CH₃)3))2TiCl₄ 
• 100654-63-5 (C₆H₄(OCH₃)C(O)NH(C(CH₃)3))2VCl₄ 
• 100654-51-1 (C₆H₄(OCH₃)C(O)NH(C(CH₃)3))2SnCl₄ 
• 100654-68-0 (C₆H₄(OCH₃)C(O)NH(C(CH₃)3))SbCl₅ 
• 100654-56-6 (C₆H₄(OCH₃)C(O)NH(C(CH₃)3))2SnBr₄ 
• 1252815-39-6 4-methoxy-2-(pyridin-2-yl)-N-tert-butylbenzamide 
• 1252815-35-2 2-iodo-4-methoxy-N-tert-butylbenzamide 
• 1252815-41-0 2-fluoro-4-methoxy-N-tert-butylbenzamide 

Relevant articles and documents

Thermolysis of 2-diazo-3-aryl ketoesters: New route to α-aryl malonates and aromatic esters

Thermochemical excitation enabled efficient α-aryl malonates synthesis from 2-diazo-3-aryl ketoesters and alcohols under transition metal-free reaction conditions. Furthermore, an unusual C[sbnd]C bond cleavage and C[sbnd]O/(N) bond formation occurred whe

Mechanistic insights and safety evaluation of the Ritter reaction utilizing tert -butyl acetate as the tert -butyl cation source

The Ritter reaction utilizing tert-butyl acetate as the tert-butyl cation source was investigated by in situ FTIR and calorimetry under various reaction conditions. It was established that, when a batch mode reaction in acetic acid was performed, minimal isobutylene was evolved into the headspace, thereby avoiding pressurization of the reaction vessel. The safety of these conditions is due to the equilibrium of isobutylene and acetic acid with tert-butyl acetate. In addition, the observation of acetic anhydride provided insight into the role of acetic acid in the mechanistic pathway.

Weak base-promoted selective rearrangement of oxaziridines to amidesviavisible-light photoredox catalysis

The selective rearrangement of oxaziridines to amidesviaa single electron transfer (SET) pathway is unexplored. In this study, we present a weak base-promoted selective rearrangement of oxaziridines to amidesviavisible-light photoredox catalysis. The developed method shows excellent functional group tolerance with a broad substrate scope and good to excellent yields. Furthermore, control experiments and density functional theory (DFT) calculations are performed to gain insight into the reactivity and selectivity.

A case study of Pd?Pd intramolecular interaction in a benzothiazole based palladacycle; catalytic activity toward amide synthesisviaan isocyanide insertion pathway

An acetate bridge benzothiazolepalladacycle containing a rare metallophilic intramolecular Pd?Pd interaction was synthesized and thoroughly characterized. The synthesized benzothiazolepalladacycle directly anchored on SBA-15 to form an efficient heterogen