19490-94-9

Basic information

• Product Name: 1-phenyl-1-(pyridin-4-yl)ethanol
• CAS NO: 19490-94-9
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.2484
• Mol File: 19490-94-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 363.2°C at 760 mmHg
• Flash Point: 173.5°C
• Density: 1.126g/cm³
• Vapor Pressure: 6.51E-06mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: 1-phenyl-1-(pyridin-4-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-1-(pyridin-4-yl)ethanol(19490-94-9)
• EPA Substance Registry System: 1-phenyl-1-(pyridin-4-yl)ethanol(19490-94-9)

Safety Data

• Hazardous Substances Data: 19490-94-9(Hazardous Substances Data)

Usage

Structure

Combination of a phenyl group and a pyridinyl group attached to an ethanol molecule the compound is formed by linking these two functional groups to the ethanol backbone.

Physical state

Colorless or light yellow liquid at room temperature the compound appears as a liquid with a pale color when at room temperature.

Molecular weight

229.29 g/mol the mass of one mole of 1-Phenyl-1-(pyridin-4-yl)ethanol is 229.29 grams.

Pharmaceutical applications

Used as a starting material for the synthesis of various drugs and pharmaceutical products the compound serves as a base for creating a range of medications and health-related products.

Organic synthesis

Used as a reagent in organic synthesis 1-Phenyl-1-(pyridin-4-yl)ethanol helps facilitate chemical reactions in the creation of other organic compounds.

Building block

Utilized as a building block in the production of various chemical compounds the compound is an essential component in the synthesis of numerous other chemicals.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 14548-46-0 4-Benzoylpyridine 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 108-86-1 bromobenzene 
• 591-51-5 phenyllithium 
• 108770-97-4 4-pyridyl phenyl sulfoxide 
• 98-86-2 acetophenone 
• 100-48-1 pyridine-4-carbonitrile 
• 100-58-3 phenylmagnesium bromide 
• 626-61-9 4-Chloropyridine 
• 71-43-2 benzene 
• 42362-47-0 1-phenyl-1-(4-pyridyl)ethane 
• 2116-65-6 4-benzyl pyridine 

Downstream Products

• 54813-56-8 1-phenyl-1-(4-pyridyl)ethylene 
• 42362-47-0 1-phenyl-1-(4-pyridyl)ethane 
• 34361-25-6 1-methyl-4-(1-phenyl-ethyl)-1,2,3,6-tetrahydro-pyridine 

Relevant articles and documents

Reductive arylation of aliphatic and aromatic aldehydes with cyanoarenes by electrolysis for the synthesis of alcohols

An electroreductive arylation reaction of aliphatic and aromatic aldehydes as well as ketones with electro-deficient (hetero)arenes is described. A variety of cyano(hetero)arenes and carbonyl compounds, especially aliphatic aldehydes, have been examined, providing secondary and tertiary alcohols in moderate to good yields. Mechanistic studies, including cyclic voltammetry (CV), electron paramagnetic resonance (EPR), and divided-cell experiments, support the generation of aliphatic ketyl radicals and persistent heteroaryl radical anions via cathodic reduction followed by radical-radical cross-coupling.

A succinic acid many west pulls sensitively impurity A preparation method (by machine translation)

The invention discloses a succinic acid many west pulls sensitively impurity A preparation method, relates to the technical field of chemical industry, comprising the following steps: to 4 - acetyl pyridine as raw material, addition reaction with the Grig

Metal-Free Synthesis of C-4 Substituted Pyridine Derivatives Using Pyridine-boryl Radicals via a Radical Addition/Coupling Mechanism: A Combined Computational and Experimental Study

Density functional theory investigations revealed that the pyridine-boryl radical generated in situ using 4-cyanopyridine and bis(pinacolato)diboron could be used as a bifunctional “reagent”, which serves as not only a pyridine precursor but also a boryl radical. With the unique reactivity of such radicals, 4-substituted pyridine derivatives could be synthesized using α,β-unsaturated ketones and 4-cyanopyridine via a novel radical addition/C-C coupling mechanism. Several controlled experiments were conducted to provide supportive evidence for the proposed mechanism. In addition to enones, the scope could be extended to a wide range of boryl radical acceptors, including various aldehydes and ketones, aryl imines and alkynones. Lastly, this transformation was applied in the late-stage modification of a complicated pharmaceutical molecule.