19491-18-0Relevant articles and documents
Selective opioid growth factor receptor antagonists based on a stilbene isostere
Stockdale, David P.,Titunick, Michelle B.,Biegler, Jessica M.,Reed, Jessie L.,Hartung, Alyssa M.,Wiemer, David F.,McLaughlin, Patricia J.,Neighbors, Jeffrey D.
, p. 4464 - 4474 (2017)
As part of an ongoing drug development effort aimed at selective opioid receptor ligands based on the pawhuskin natural products we have synthesized a small set of amide isosteres. These amides were centered on lead compounds which are selective antagonis
Regioselective bromination: An approach to the D-ring of the gilvocarcins
Sharif, Ehesan U.,O'Doherty, George A.
, p. 1275 - 1285 (2014)
A method for the regioselective ortho-bromination of unsymmetrically protected 3,5-dihydroxybenzoic acid esters has been developed. The route involves protecting group optimization studies to attain high regioselectivity for the ortho-bromination. Pd-catalyzed stannation and boration were performed to construct the D-ring coupling partners for the synthesis of gilvocarcin analogs.
ENHANCING AUTOPHAGY OR INCREASING LONGEVITY BY ADMINISTRATION OF UROLITHINS OR PRECURSORS THEREOF
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Sheet 33, (2014/01/17)
Disclosed are methods, compounds, and compositions useful for increasing autophagy and promoting longevity. The methods, compounds, and compositions relate to urolithins and urolithin precursors and use thereof. Certain urolithins are represented by Formula I, while certain urolithin precursors are represented by Formula IV. The urolithin may be urolithin A, urolithin B, urolithin C, or urolithin D. The urolithin precursor may be ellagic acid or an ellagitannin. The methods include in vivo, ex vivo, and in vitro uses of the compounds and compositions.
