74726-76-4Relevant articles and documents
Synthesis of [6,6,m]-Tricyclic Compounds via [4+2] Cycloaddition with Au or Cu Catalyst
Kang, Juyeon,Ham, Seunghwan,Seong, Chaehyeon,Oh, Chang Ho
, p. 1039 - 1043 (2021/05/05)
We synthesized [6,6,6]- and [6,6,7]-tricyclic compounds via intramolecular [4+2] cycloaddition by gold or copper catalysts. Substrates for cyclization were prepared by coupling reactions between eight types of diyne and four types of aromatic moieties. We have successfully synthesized eleven tricyclic compounds.
Regioselective bromination: An approach to the D-ring of the gilvocarcins
Sharif, Ehesan U.,O'Doherty, George A.
, p. 1275 - 1285 (2016/11/11)
A method for the regioselective ortho-bromination of unsymmetrically protected 3,5-dihydroxybenzoic acid esters has been developed. The route involves protecting group optimization studies to attain high regioselectivity for the ortho-bromination. Pd-catalyzed stannation and boration were performed to construct the D-ring coupling partners for the synthesis of gilvocarcin analogs.
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
Zhang, Yi-Nan,Zhong, Xiang-Gen,Zheng, Zong-Ping,Hu, Xu-Dong,Zuo, Jian-Ping,Hu, Li-Hong
, p. 988 - 996 (2007/10/03)
Three new alkaloids (1-3) and twenty-one known compounds were isolated from the stem of Fissistigma oldhamii (Hemsl.) Merr. which was the ruler herb in an approved Traditional Chinese herbal formula used for treatment of rheumatoid arthritis in China and synthesis of one new immunosuppressive alkaloid was achieved. These compounds, including the crude extracts of this herb, exhibited strong activities in the inhibition of T and B cell proliferation.