195136-63-1

Basic information

• Product Name: Benzene, 1,3-difluoro-2,4-dimethoxy-5-nitro-
• CAS NO: 195136-63-1
• Molecular Formula: C8H7F2NO4
• Molecular Weight: 219.145
• Mol File: 195136-63-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzene, 1,3-difluoro-2,4-dimethoxy-5-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,3-difluoro-2,4-dimethoxy-5-nitro-(195136-63-1)
• EPA Substance Registry System: Benzene, 1,3-difluoro-2,4-dimethoxy-5-nitro-(195136-63-1)

Safety Data

• Hazardous Substances Data: 195136-63-1(Hazardous Substances Data)

Upstream product

• 5580-79-0 2,3,4,5-tetrafluoro-1-nitrobenzene 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 551-62-2 1,2,3,4-tetrafluorobenzene 

Downstream Products

• 195136-67-5 1-amino-3,5-difluoro-2,4-dimethoxybenzene 
• 215868-23-8 6,8-difluoro-7-hydroxy-4-methyl-2H-chromen-2-one 
• 215868-26-1 6',8'-difluoro-4’-methylumbelliferyl α-D-glucopyranoside 
• 215868-31-8 6,8-difluoro-7-hydroxycoumarin-3-carboxylic acid 
• 209541-27-5 3,5-Difluoro-2,4-dihydroxybenzaldehyde 
• 195136-69-7 2,4-difluoro-1,3-dimethoxybenzene 
• 195136-71-1 2,4-difluorobenzene-1,3-diol 

Relevant articles and documents

Palladium-Mediated Approach to Coumarin-Functionalized Amino Acids

Incorporation of the fluorogenic l-(7-hydroxycoumarin-4-yl)ethylglycine into proteins is a valuable biological tool. Coumarins are typically accessed via the Pechmann reaction, which requires acidic conditions and lacks substrate flexibility. A Pd-mediated coupling is described between o-methoxyboronic acids and a glutamic acid derived (Z)-vinyl triflate, forming latent coumarins. Global deprotection with BBr3 forms the coumarin scaffold in a single step. This mild and scalable route yielded five analogues, including a probe suitable for use at lower pH.

FLUORINATED 4' ALKYLUMBELLIFERYL α-D-GLUCOPYRANOSIDES, BIOLOGICAL STERILIZATION INDICATORS INCLUDING THE SAME AND METHODS OF USING THE SAME

A self-contained biological sterilization indicator comprises: a housing; bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of an enzyme substrate; and a frangible container containing a composition, wherein the composition comprises the enzyme substrate, wherein if the frangible container is broken the composition will contact the bacterial spores to form a mixture having an initial pH in the range from 6.0 to 9.0. The enzyme substrate comprises a fluorinated 4'-alkylumbelliferyl α-D-glucopyranoside represented by the structural formula (I) wherein one of R1 and R2 is F and the other is H, and R3 is an alkyl group having from 1 to 12 carbon atoms. A biological sterilization indicator comprising a kit containing isolated components comprising (i) bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of the enzyme substrate and a method of assessing efficacy of a sterilization process are also disclosed.

Aarhus sensor green: A fluorescent probe for singlet oxygen

A tetrafluoro-substituted fluorescein derivative covalently linked to a 9,10-diphenyl anthracene moiety has been synthesized, and its photophysical properties have been characterized. This compound, denoted Aarhus Sensor Green (ASG), has distinct advantages for use as a fluorescent probe for singlet molecular oxygen, O2(a1δg). In the least, ASG overcomes several limitations inherent to the use of the related commercially available product called Singlet Oxygen Sensor Green (SOSG). The functional behavior of both ASG and SOSG derives from the fact that these weakly fluorescent compounds rapidly react with singlet oxygen via a π2 + π4 cycloaddition to irreversibly yield a highly fluorescent endoperoxide. The principal advantage of ASG over SOSG is that, at physiological pH values, both ASG and the ASG endoperoxide (ASG-EP) do not themselves photosensitize the production of singlet oxygen. As such, ASG better fits the requirement of being a benign probe. Although ASG readily enters a mammalian cell (i.e., HeLa) and responds to the presence of intracellular singlet oxygen, its behavior in this arguably complicated environment requires further investigation.