5580-79-0 Usage
Description
2,3,4,5-Tetrafluoronitrobenzene, with the CAS number 5580-79-0, is a polyfluoroarene compound characterized by its clear yellow liquid appearance. It is known for its reactivity in various chemical processes, such as mercuration and nucleophilic aromatic substitution reactions with substances like methanol.
Uses
Used in Organic Synthesis:
2,3,4,5-Tetrafluoronitrobenzene is used as a key intermediate in the field of organic synthesis for the production of various compounds. Its unique structure and reactivity make it a valuable component in the synthesis of complex organic molecules.
Used in Mercuration Reactions:
In the chemical industry, 2,3,4,5-tetrafluoronitrobenzene is used as a reactant in mercuration reactions, which involve the addition of a mercury compound to the molecule. This process can lead to the formation of new compounds with different properties and applications.
Used in Nucleophilic Aromatic Substitution:
2,3,4,5-Tetrafluoronitrobenzene is also utilized in nucleophilic aromatic substitution reactions, particularly with methanol. This reaction can result in the formation of para-substituted diaryl sulfides, which have potential applications in various chemical and pharmaceutical processes.
Overall, 2,3,4,5-tetrafluoronitrobenzene is a versatile compound with a range of applications in the chemical industry, particularly in organic synthesis, mercuration reactions, and nucleophilic aromatic substitution processes. Its unique properties and reactivity make it a valuable asset in the development of new compounds and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 5580-79-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,5,8 and 0 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5580-79:
(6*5)+(5*5)+(4*8)+(3*0)+(2*7)+(1*9)=110
110 % 10 = 0
So 5580-79-0 is a valid CAS Registry Number.
InChI:InChI=1/C6HF4NO2/c7-2-1-3(11(12)13)5(9)6(10)4(2)8/h1H
5580-79-0Relevant articles and documents
Transition-Metal-Free Catalytic Hydrodefluorination of Polyfluoroarenes by Concerted Nucleophilic Aromatic Substitution with a Hydrosilicate
Kikushima, Kotaro,Grellier, Mary,Ohashi, Masato,Ogoshi, Sensuke
supporting information, p. 16191 - 16196 (2017/11/27)
A transition-metal-free catalytic hydrodefluorination (HDF) reaction of polyfluoroarenes is described. The reaction involves direct hydride transfer from a hydrosilicate as the key intermediate, which is generated from a hydrosilane and a fluoride salt. The eliminated fluoride regenerates the hydrosilicate to complete the catalytic cycle. Dispersion-corrected DFT calculations indicated that the HDF reaction proceeds through a concerted nucleophilic aromatic substitution (CSNAr) process.
Copper-catalyzed hydrodefluorination of fluoroarenes by copper hydride intermediates
Lv, Hongbin,Cai, Yuan-Bo,Zhang, Jun-Long
supporting information, p. 3203 - 3207 (2013/04/23)
Breaking bad: Efficient copper-catalyzed C-F bond activation has been achieved by replacing fluorine with hydrogen. A copper hydride is proposed as the active intermediate, which proceeds through a nucleophilic attack on the fluorocarbon, as determined by experimental and theoretical results (see structure; C gray, H white, Cu light red, F light blue; distances in ?).
Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
-
, (2008/06/13)
Novel difluoro-naphthyridine- and trifluoroquinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
