196295-98-4

Basic information

• Product Name: (1R,2S,3S,5S)-3-(3,4-Dichloro-phenyl)-8-prop-2-ynyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester
• Synonyms: (1R,2S,3S,5S)-3-(3,4-Dichloro-phenyl)-8-prop-2-ynyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester
• CAS NO: 196295-98-4
• Molecular Weight: 352.26
• Mol File: 196295-98-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2S,3S,5S)-3-(3,4-Dichloro-phenyl)-8-prop-2-ynyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,3S,5S)-3-(3,4-Dichloro-phenyl)-8-prop-2-ynyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester(196295-98-4)
• EPA Substance Registry System: (1R,2S,3S,5S)-3-(3,4-Dichloro-phenyl)-8-prop-2-ynyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester(196295-98-4)

Safety Data

• Hazardous Substances Data: 196295-98-4(Hazardous Substances Data)

Upstream product

• 106-96-7 propargyl bromide 
• 146725-34-0 O-456 
• 72393-99-8 anhydroecgonine acid chloride 
• 143965-99-5 dicholoropane 
• 53-21-4 (-)-cocaine hydrochloride 
• 79175-35-2 3,4-dichlorophenylmagnesium bromide 

Downstream Products

• 188680-64-0 (1R,2S,3S,5S)-3-(3,4-Dichloro-phenyl)-8-((E)-3-tributylstannanyl-allyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis of iodinated and radioiodinated (E)-N-(3-iodoprop-2-enyl)-2β-carbomethoxy-3β-(3',4'-dichlorophenyl) notropane (β-CDIT): A ligand for the dopamine transporter

The synthesis of (E)-N-(3-iodoprop-2-enyl)-2β-carbomethoxy-3β-(3',4'-dichlorophenyl) nortropane (β-CDIT) and its radioiodinated analogues is described. Three different synthetic methods are reported for the preparation of (E)-N-[3-(tributylstannyl)-2-enyl]-2β-carbomethoxy-3β-(3', 4'-dichlorophenyl) nortropane, which was iododestannylated for the preparation of the corresponding iodinated derivative. We also report the radiolabelling of β-CDIT with 125I or 123I that could be used for in vitro and in vivo exploration of the dopamine transporter.