1965-25-9

Basic information

• Product Name: 1-azido-2,4-dichlorobenzene
• Synonyms: 1-Azido-2,4-dichlorobenzene; 2,4-Dichlorophenyl azide; benzene, 1-azido-2,4-dichloro-
• CAS NO: 1965-25-9
• Molecular Formula: C₆H₃Cl₂N₃
• Molecular Weight: 188.0141
• Mol File: 1965-25-9.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 1-azido-2,4-dichlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-azido-2,4-dichlorobenzene(1965-25-9)
• EPA Substance Registry System: 1-azido-2,4-dichlorobenzene(1965-25-9)

Safety Data

• Hazardous Substances Data: 1965-25-9(Hazardous Substances Data)

Upstream product

• 554-00-7 2,4-Dichloroaniline 
• 75458-14-9 5-Chloro-2-azidoaniline 
• 1635-61-6 5-chloro-2-nitroaniline 
• 17537-08-5 4-Chloro-2-phthalimidoaniline 
• 17537-07-4 4-Chloro-2-phthalimidonitrobenzene 
• 17537-13-2 4-Chloro-2-phthalimidoazidobenzene 
• 29898-32-6 2,4-dichloro-1-iodo-benzene 

Downstream Products

• 92886-52-7 N-(2,4-dichlorophenyl)triphenylphosphine imide 
• 114462-80-5 1-(2,4-Dichloro-phenyl)-5-methoxycarbonylmethyl-1H-[1,2,3]triazole-4-carboxylic acid methyl ester 
• 65245-74-1 C₁₃H₁₁Cl₂N₅ 
• 554-00-7 2,4-Dichloroaniline 
• 296778-52-4 tert-butyl (2,4-dichlorophenyl)carbamate 
• 114462-86-1 5-(Diazo-methoxycarbonyl-methyl)-1-(2,4-dichloro-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester 
• 252654-01-6 3-(2,4-dichloro-phenyl)-5-(4-methoxy-phenyl)-3H-[1,2,3]triazol-4-ylamine 
• 1115300-78-1 4-[5-amino-1-(2,4-dichloro-phenyl)-1H-[1,2,3]triazol-4-yl]-benzonitrile 
• 1115300-52-1 5-(5-chloro-2-methoxy-phenyl)-3-(2,4-dichloro-phenyl)-3H-[1,2,3]triazol-4-ylamine 
• 1133438-93-3 HS₅₇-6 
• 1133438-85-3 HS₅₇-2 
• 1133438-90-0 ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1H-1,2,3-triazole-4-carboxylate 
• 1133438-95-5 HS₅₇-9 
• 1133438-87-5 methyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1,2,3-triazole-4-carboxylate 

Relevant articles and documents

Synthesis, antiproliferative, docking and DFT studies of benzimidazole derivatives as EGFR inhibitors

In the present work, new benzimidazole linked 1,2,3-triazole hybrids have been synthesized and screened for antiproliferative and EGFR kinase inhibitory activities.The structures of these hybrids were elucidated using IR, NMR, mass spectrometry and elemen

Naproxen based 1,3,4-oxadiazole derivatives as EGFR inhibitors: Design, synthesis, anticancer, and computational studies

A library of novel naproxen based 1,3,4-oxadiazole derivatives (8–16 and 19–26) has been synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized hy-brids, compound2-(4-((5-((S)-1-(2-methoxynaphthalen-6-yl)ethyl)-1,3,4-oxadiazol-2-ylthio)methyl)-1H-1,2,3-triazol-1-yl)phenol(15) was the most potent compound against MCF-7 and HepG2cancer cells with IC50 of 2.13 and 1.63 μg/mL, respectively, and was equipotent to doxorubicin (IC50 1.62 μg/mL) towards HepG2. Furthermore, compound 15 inhibited EGFR kinase with IC50 0.41 μM compared to standard drug Erlotinib (IC50 0.30 μM). The active compound induces a high percentage of necrosis towards MCF-7, HePG2 and HCT 116 cells. The docking studies, DFT and MEP also supported the biological data. These results demonstrated that these synthesized naproxen hybrids have EGFR inhibition effects and can be used as leads for cancer therapy.

Synthesis, characterization and photodynamic activity against bladder cancer cells of novel triazole-porphyrin derivatives

Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of