196603-96-0

Basic information

• Product Name: 4-(4-bromo-2-fluorophenylamino)-6-methoxyquinazolin-7-ol
• Synonyms: 4-(4-bromo-2-fluorophenylamino)-6-methoxyquinazolin-7-ol;4-(4-Bromo-2-fluoroanilino)-7-hydroxy-6-methoxyquinazoline;6-Methoxy-7-hydroxy-4-(2''-fluoro-4''-broMoaniline)quinazoline;7-Quinazolinol, 4-[(4-broMo-2-fluorophenyl)aMino]-6-Methoxy-;4-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-Quinazolinol
• CAS NO: 196603-96-0
• Molecular Formula: C₁₅H₁₁BrFN₃O₂
• Molecular Weight: 364
• EINECS: 1806241-263-5
• Mol File: 196603-96-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 268-270 °C
• Boiling Point: 470.985 °C at 760 mmHg
• Flash Point: 238.643 °C
• Appearance: /
• Density: 1.663
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 5.51±0.40(Predicted)
• CAS DataBase Reference: 4-(4-bromo-2-fluorophenylamino)-6-methoxyquinazolin-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-bromo-2-fluorophenylamino)-6-methoxyquinazolin-7-ol(196603-96-0)
• EPA Substance Registry System: 4-(4-bromo-2-fluorophenylamino)-6-methoxyquinazolin-7-ol(196603-96-0)

Safety Data

• Hazardous Substances Data: 196603-96-0(Hazardous Substances Data)

Usage

Uses

4-(4-Bromo-2-fluoroanilino)-7-hydroxy-6-methoxyquinazolin is used in the synthesis of [18F]-(R)-FEPAQ, a potential PET imaging agent for VEGFR2. This would be helpful in the imaging of VEGFR in cance r patients.

Upstream product

• 768350-54-5 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine hydrochloride 
• 367-24-8 4-bromo-2-fluoroaniline 
• 60547-98-0 2-amino-4-benzyloxy-5-methoxybenzamide 
• 179688-01-8 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one 
• 193001-44-4 7-benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride 
• 162364-72-9 7-benzyloxy-4-chloro-6-methoxyquinazoline 
• 60547-92-4 4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid 
• 2426-84-8 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde 
• 60547-94-6 5-Methoxy-2-nitro-4-(phenylmethoxy)benzamide 
• 179688-01-8 7-(benzyloxy)-6-methoxyquinazolin-4(3H)-one 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 185033-64-1 ethyl 4-benzyloxy-3-methoxybenzoate 
• 617-05-0 ethyl vanillate 
• 4421-08-3 3-methoxy-4-hydroxybenzonitrile 

Downstream Products

• 413599-62-9 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,3-triazol-1-yl)ethoxy]quinazoline-4-amine 
• 413599-49-2 tert-butyl 4-[2-({4-[(4-bromo-2-fluorophenyl)amino]-6-methylquinazolin-7-yl}oxy)ethyl]piperidine-1-carboxylate 
• 205194-14-5 N-(4-bromo-2-fluorophenyl)-7-(3-chloropropoxy)-6-methoxyquinazolin-4-amine 
• 338992-20-4 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester 
• 338992-12-4 N-Desmethylvandetanib 
• 413599-48-1 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-[2-(piperidin-4-yl)ethoxy]quinazoline 
• 867150-30-9 (4R,6S)-{6-[4-(4-bromo-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxymethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-acetic acid ethyl ester 
• 205193-61-9 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(3-methylthiopropoxy)quinazoline 
• 205193-78-8 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(3-(2-oxypyrrolidin-1-yl)propoxy)quinazoline hydrochloride 
• 205194-23-6 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(3-methylaminopropoxy)quinazoline 
• 205193-97-1 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(2-(3-oxomorpholino)ethoxy)quinazoline hydrochloride 
• 205193-98-2 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(2-(2-oxopyrrolidin-1-yl)ethoxy)quinazoline hydrochloride 
• 910298-60-1 4-((4-bromo-2-fluorophenyl)amino)-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-6-ol 

Relevant articles and documents

A where the shall he loni intermediate and its preparation method

The present invention provides a where the shall he loni intermediate and its preparation method, the where the shall he loni intermediate by compound 8 in the sodium methoxide or metal lithium, sodium, potassium and the like under the action 9 acidifying the resulting: Wherein X fluorine, chlorine, bromine, move in the halogen, R3 is lithium, sodium, potassium and the like metal. The invention conducive to product quality control, the reaction condition is more simple, moderate, environmental protection, high requirements on equipment, each step the reaction yield is higher.

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Synthesis and in vitro evaluation of [18F](R)-FEPAQ: A potential PET ligand for VEGFR2

Synthesis and in vitro evaluation of [18F](R)-N-(4-bromo-2- fluorophenyl)-7-((1-(2-fluoroethyl)piperidin-3-yl)methoxy)-6-methoxyquinazolin- 4-amine ((R)-[18F]FEPAQ or [18F]1), a potential imaging agent for the VEGFR2, usin